1.14.13.59: L-lysine N6-monooxygenase (NADPH)

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For detailed information about L-lysine N6-monooxygenase (NADPH), go to the full flat file.

Reaction

Synonyms

EC 1.13.12.10, EC 13.12.10, flavin-dependent lysine monooxygenase, flavin-dependent N6-lysine monooxygenase, IucD, LH, lysine monooxygenase, Lysine N(6)-hydroxylase, Lysine N6-hydroxylase, lysine N6-monooxygenase, lysine: N6-hydroxylase, lysine:N(6)-hydroxylase, Lysine:N6-hydroxylase, MbsG, N-hydroxylating monooxygenase, NbtG, Oxygenase, lysine N6-mono-

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.59 L-lysine N6-monooxygenase (NADPH)

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Results	in table
4	Activating Compound
6102	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
36	Cofactor
1	Crystallization (Commentary)
4	General Information
1	General Stability
10	Inhibitors
20	kcat/KM [mM/s]
1	Ki Value [mM]
38	KM Value [mM]
5	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
19	Organism
8	Pathway
4	PDB ID
7	pH Optimum
2	pH Range
25	Protein Variants
4	Purification (Commentary)
5	Reaction
2	Reaction Type
17	Reference
9	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

General Information

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General Information on EC 1.14.13.59 - L-lysine N6-monooxygenase (NADPH)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

3 entries

additional information

Nocardia farcinica

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an unexpected protein conformation with a 30° rotation of the NAD(P)H domain with respect to the flavin adenine dinucleotide (FAD) domain precludes binding of the nicotinamide cofactor

745322

physiological function

Mycolicibacterium smegmatis

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Mycobacterium smegmatis G (MbsG) is a flavin-dependent L-lysine monooxygenase involved in the biosynthesis of the siderophore mycobactin, overview

744158

physiological function

Nocardia farcinica

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the flavoenzyme catalyzes the NADPH-and oxygen-dependent hydroxylation of lysine, NbtG utilizes NADPH and molecular oxygen to hydroxylate the Nepsilon-atom of L-Lys. NbtG is unable to stabilize the FADOOH intermediate, which results in production of hydrogen peroxide and superoxide. The biosynthesis of the siderophore nocobactin in Nocardia farcinica requires functioning of NbtG

745322

physiological function

Mycolicibacterium smegmatis G

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Mycobacterium smegmatis G (MbsG) is a flavin-dependent L-lysine monooxygenase involved in the biosynthesis of the siderophore mycobactin, overview

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