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1.14.13.54: ketosteroid monooxygenase

This is an abbreviated version!
For detailed information about ketosteroid monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.54

Reaction

17alpha-hydroxyprogesterone
+
NADPH
 +
H+
 +
O2
=
androstenedione
 +
acetate
 +
NADP+
 +
H2O

Synonyms

17alpha-Hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), Androgen hydroxylase, Androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing), Baeyer-Villiger monooxygenase, BVMO, CYP106A2, Hydroxylase, steroid, NADPH-dependent steroid Baeyer-Villiger monooxygenase, Oxygenase, steroid mono-, Progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), Steroid hormone hydroxylase, Steroid hydroxylase, steroid hydroxylating cytochrome, Steroid monooxygenase, Steroid-ketone monooxygenase, STMO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.54 ketosteroid monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.54 - ketosteroid monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
11-deoxycortisol + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
11beta-Hydroxyprogesterone + NADPH + O2
?
show the reaction diagram
17alpha-hydroxypregnenolone + NADPH + O2
?
show the reaction diagram
17alpha-Hydroxyprogesterone + NADPH + O2
androstenedione + acetate + NADP+ + H2O
show the reaction diagram
18-Hydroxydeoxycorticosterone + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
21-Deoxycortisol + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
Aldosterone + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
androstenedione + NADPH + O2
3-oxo-13,17-secoandrost-4-eno-17,13-alpha-lactone + NADP+ + H2O
show the reaction diagram
Corticosterone + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
Cortisol + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
Cortisone + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
deoxycorticosterone + NADPH + O2
?
show the reaction diagram
phenylacetone + NADPH + H+ + O2
benzylacetate + NADP+ + H2O
show the reaction diagram
-
-
-
?
Pregnenolone + NADPH + O2
?
show the reaction diagram
progesterone + NADPH + H+ + O2
Testosterone acetate + NADP+ + H2O
show the reaction diagram
additional information
?
-
-
the enzyme does not accept 3beta-hydroxy-5-ene steroids as substrates
-
-
?