1.14.13.39: nitric-oxide synthase (NADPH)

This is an abbreviated version!
For detailed information about nitric-oxide synthase (NADPH), go to the full flat file.

Reaction

2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP⁺ + 2 H2O

Synonyms

bacterial nitric oxide synthase, bacterial nitric-oxide synthase, bNOS, bsNOS, cb-NOS, cytokine inducible NOS, DNOS, e-NOS, EC-NOS, endothelial nitric oxide synthase, endothelial nitric-oxide synthase, endothelial NO synthase, endothelial NOS, endothelium-derived relaxation factor-forming enzyme, endothelium-derived relaxing factor synthase, eNOS, i-NOS, inducible nitric oxide synthase, inducible nitric-oxide synthase, inducible NO synthase, inducible NOS, iNOS, mitochondrial NO synthase, mitochondrial-specific nitric oxide synthase, mtNOS, n-NOS, NADPH diaphorase, NADPH-d, NADPH-diaphorase, NADPHd, neuronal nitric oxide synthase, neuronal nitric-oxide synthase, neuronal NO synthase, neuronal NOS, nicotinamide adenine dinucleotide phosphate-diaphorase, nitric oxid synthase, nitric oxide synthase, nitric oxide synthase-like protein, nitric oxide synthetase, nitric-oxide synthase, nNOS, nNOSalpha, NO synthase, NO synthase type I, NO synthase type II, NO synthase type III, NO-synthase, NOS, NOS I, NOS-2, NOS1, NOS2, NOS3, synthetase, nitric oxide

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.39 nitric-oxide synthase (NADPH)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
52	Activating Compound
4387	AA Sequence
6	Application
1	CAS Registry Number
52	Cloned(Commentary)
373	Cofactor
6	Crystallization (Commentary)
40825	Disease/ Diagnostics
26	Expression
36	General Information
18	General Stability
23	IC50 Value
214	Inhibitors
51	Ki Value [mM]
99	KM Value [mM]
96	Localization
113	Metals/Ions
51	Molecular Weight [Da]
106	Natural Substrates/ Products (Substrates)
2027	Organism
5	Pathway
1313	PDB ID
49	pH Optimum
1	pH Range
4	pH Stability
10	Posttranslational Modification
43	Protein Variants
66	Purification (Commentary)
31	Reaction
3	Reaction Type
220	Reference
1	Renatured (Commentary)
434	Source Tissue
57	Specific Activity [micromol/min/mg]
14	Storage Stability
324	Substrates and Products (Substrate)
68	Subunits
320	Synonyms
1	Systematic Name
72	Temperature Optimum [°C]
3	Temperature Stability [°C]
25	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Crystallization on EC 1.14.13.39 - nitric-oxide synthase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Crystallization (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with inhibitor AR

Homo sapiens

-

660371

sitting drop vapor diffusion method

Homo sapiens

P29474, P29475

699457

in complex with inhibitor AR

Mus musculus

P29477

660371

orthorhombic crystals from NOS oxygenase domain lacking the N-terminal 114 residues, preparation in presence of imidazole, structure analysis via x-ray diffraction, also with bound inhibitor N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-4-(methoxycarbonyl)-piperazine-2-acetamide

Mus musculus

P29477

440219

x-ray crystal structure of the heme-binding domains of neuronal wild-type and mutant with deletion in the heme-binding domain

Mus musculus

-

440217

in complex with inhibitor AR

Rattus norvegicus

P29476

660371