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1.14.13.34: leukotriene-E4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-E4 20-monooxygenase, go to the full flat file.

Reaction

(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
+
NADPH
+
H+
+
O2
=
20-hydroxyleukotriene E4
+
NADP+
+
H2O

Synonyms

leukotriene-E4 omega-hydroxylase, oxygenase, leukotriene E4 20-mono

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.34 leukotriene-E4 20-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.34 - leukotriene-E4 20-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase.