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1.14.13.34: leukotriene-E4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-E4 20-monooxygenase, go to the full flat file.

Reaction

(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
+
NADPH
+
H+
+
O2
=
20-hydroxyleukotriene E4
+
NADP+
+
H2O

Synonyms

leukotriene-E4 omega-hydroxylase, oxygenase, leukotriene E4 20-mono

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.34 leukotriene-E4 20-monooxygenase

Reference

Reference on EC 1.14.13.34 - leukotriene-E4 20-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Orning, L.
omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes
Eur. J. Biochem.
170
77-85
1987
Rattus norvegicus
Manually annotated by BRENDA team
Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro
Eur. J. Biochem.
206
869-897
1992
Rattus norvegicus
Manually annotated by BRENDA team