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1.14.13.34: leukotriene-E4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-E4 20-monooxygenase, go to the full flat file.

Reaction

(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
+
NADPH
+
H+
+
O2
=
20-hydroxyleukotriene E4
+
NADP+
+
H2O

Synonyms

leukotriene-E4 omega-hydroxylase, oxygenase, leukotriene E4 20-mono

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.34 leukotriene-E4 20-monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.34 - leukotriene-E4 20-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
-
competitively inhibits leukotriene E4 omega-oxidation
Halothane
-
induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme