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1.14.13.29: 4-nitrophenol 2-monooxygenase

This is an abbreviated version!
For detailed information about 4-nitrophenol 2-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.29

Reaction

4-nitrophenol
+
NADH
+
H+
+
O2
=
4-nitrocatechol
+
NAD+
+
H2O

Synonyms

4-nitrophenol 4-monooxygenase/4-nitrocatechol 2-monooxygenase, 4-nitrophenol hydroxylase, 4-nitrophenol-2-hydroxylase, 4-NPH, CYP 2E1, CYP2A/2E1, CYP2E1, cytochrome P-450 2E1, cytochrome P-450 isozyme 3a, NphA1, oxygenase, 4-nitrophenol 2-mono-, p-nitrophenol 2-hydroxylase, p-nitrophenol hydroxylase, p-nitrophenol hydroxylase component A, p-nitrophenol-hydroxylase, PNP 2-monooxygenase, PNP monooxygenase, PnpA1, PNPH, PPH, two-component 4-nitrophenol hydroxylase, two-component PNP monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.29 4-nitrophenol 2-monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.29 - 4-nitrophenol 2-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-nitrophenol
alpha-naphthoflavone
-
slight
catalase
-
30% inhibition at 1000 units
-
chlorzoxazone
-
mutual competitive inhibition with 4-nitrophenol
Co2+
-
slight effect, crude enzyme extract
coumarin
-
slight
Cu2+
-
94% inhibition at 1 mM,crude enzyme extract
diethyldithiocarbamate
-
50% inhibition at 0.002-0.003 mM
FAD
inhibition at concentrations higher than 10 microM FAD, complete inhibition at concentrations higher than 50 microM FAD
Fe2+
-
slight effect, crude enzyme extract
Fe3+
-
slight effect, crude enzyme extract
Hg2+
-
63% inhibition at 1 mM, crude enzyme extract
Horseradish peroxidase
-
complete inhibition at 25 units
-
mephenytoin
-
slight
N-Methylmaleimide
-
84% inhibition at 5 mM
Ni2+
-
slight effect, crude enzyme extract
p-chloromercuribenzoate
-
81% inhibition at 1 mM
quinidine
-
slight
sesamin
Sn2+
-
57% inhibition at 1 mM,crude enzyme extract
sulfaphenazole
-
slight
troleandomycin
-
slight
additional information
-