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1.14.13.243: toluene 2-monooxygenase

This is an abbreviated version!
For detailed information about toluene 2-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.243

Reaction

2-methylphenol
+
NADH
+
H+
+
O2
=
3-methylcatechol
+
NAD+
+
H2O

Synonyms

toluene ortho-monooxygenase, tomA1/2/3/4/5

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.243 toluene 2-monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.243 - toluene 2-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-butyne
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities. Presence of oxygen, supplied as H2O2, is required for inhibition by 1-butyne
1-hexyne
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities
2-hexyne
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities
3-hexyne
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities
Acetylene
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
10-50% vol/vol gas phase required for inhibition of growth on toluene
Trichloroethylene
Q9ANX4; Q9ANX0; Q9ANX3; Q8VSV8; Q9ANX1; Q8VSV9
trichloroethylene-dependent inactivation of toluene 2-monooxygenase activity
additional information
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