1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

This is an abbreviated version!
For detailed information about 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase, go to the full flat file.

Reaction

Synonyms

2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase, 2-methyl-3-hydroxypyridine 5-carboxylic acid oxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 3-hydroxy-2-methylpyridine carboxylate dioxygenase, 3-hydroxy-2-methylpyridinecarboxylate dioxygenase, EC 1.14.12.4, methylhydroxypyridine carboxylate dioxygenase, methylhydroxypyridinecarboxylate oxidase, MHPCO, mlr6788

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

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Results	in table
7	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
8	Crystallization (Commentary)
10	General Information
1	IC50 Value
8	Inhibitors
3	kcat/KM [mM/s]
2	Ki Value [mM]
21	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
42	Organism
1	Oxidation Stability
3	Pathway
3	pH Optimum
19	Protein Variants
7	Purification (Commentary)
6	Reaction
3	Reaction Type
25	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
46	Substrates and Products (Substrate)
6	Subunits
38	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.13.242 - 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-methyl-3-hydroxypyridine-5-carboxylic acid + NADH + O2 + H+

2-(acetamidomethylene)succinate + NAD+

Mesorhizobium loti

Q988D3

-

742939

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2

2-(acetamidomethylidene)succinate + NAD(P)+

3 entries

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2

2-(acetamidomethylene)succinate + NAD+

3 entries

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2

2-(acetamidomethylene)succinate + NAD+

2 entries

3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + H+ + O2

2-(acetamidomethylene)succinate + NADP+

Pseudomonas sp. MA-1

-

-

742494

-

-

?

5-hydroxynicotinic acid + NADH + O2 + H+

2-(formylamidomethylene)succinate + NAD+

Mesorhizobium loti

Q988D3

about 100% of the activity with 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?

5-pyridoxic acid + NADH + O2 + H+

2-(acetamidomethylene)-beta-hydroxymethyl succinate + NAD+

Mesorhizobium loti

Q988D3

5% of the activity with 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?

additional information

?

-

4 entries

3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2

2-(acetamidomethylidene)succinate + NAD(P)+

Mesorhizobium japonicum

Q988D3

-

763846

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2

2-(acetamidomethylidene)succinate + NAD(P)+

Mesorhizobium japonicum CECT 9101

Q988D3

-

763846

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2

2-(acetamidomethylidene)succinate + NAD(P)+

Mesorhizobium japonicum LMG 29417

Q988D3

-

763846

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2

2-(acetamidomethylene)succinate + NAD+

Mesorhizobium loti

Q988D3

-

742939

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2

2-(acetamidomethylene)succinate + NAD+

Mesorhizobium loti MAFF 303099

Q988D3

-

742939

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2

2-(acetamidomethylene)succinate + NAD+

Mesorhizobium loti MAFF303099

Q988D3

-

742939

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2

2-(acetamidomethylene)succinate + NAD+

Pseudomonas sp.

-

inducible enzyme opens the pyridine ring during the metabolic degradation of vitamin B6

439054

-

-

?

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2

2-(acetamidomethylene)succinate + NAD+

Pseudomonas sp.

-

enzyme is involved in degradation of vitamin B6

439060

-

-

?

additional information

?

-

Mesorhizobium loti

Q988D3

also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?

additional information

?

-

Mesorhizobium loti

-

also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?

additional information

?

-

Mesorhizobium loti MAFF 303099

Q988D3

also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?

additional information

?

-

Mesorhizobium loti MAFF303099

Q988D3

also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of 2-methyl-3-hydroxypyridine-5-carboxylic acid

742939

-

-

?