1.14.13.236: toluene 4-monooxygenase

This is an abbreviated version!
For detailed information about toluene 4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.236

Reaction

Toluene
+
NADH
+
H+
+
O2
=
4-Methylphenol
+
NAD+
+
H2O

Synonyms

T4moD, T4moF, T4MOH, TMO, TmoA, TmoC, TmoF, toluene-4-monooxygenase system protein A, TOM, TomA3

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.236 toluene 4-monooxygenase

Reference

Reference on EC 1.14.13.236 - toluene 4-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwartz, J.K.; Wei, P.P.; Mitchell, K.H.; Fox, B.G.; Solomon, E.I.
Geometric and electronic structure studies of the binuclear nonheme ferrous active site of toluene-4-monooxygenase: parallels with methane monooxygenase and insight into the role of the effector proteins in O2 activation
J. Am. Chem. Soc.
130
7098-7109
2008
Pseudomonas mendocina (Q00456 and Q00457 and Q00460), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460)
Manually annotated by BRENDA team
Feingersch, R.; Shainsky, J.; Wood, T.K.; Fishman, A.
Protein engineering of toluene monooxygenases for synthesis of chiral sulfoxides
Appl. Environ. Microbiol.
74
1555-1566
2008
Pseudomonas mendocina (Q00456), Burkholderia cepacia (Q9ANX2), Burkholderia cepacia G4 (Q9ANX2), Burkholderia cepacia G4, Pseudomonas mendocina KR1 (Q00456), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Brouk, M.; Nov, Y.; Fishman, A.
Improving biocatalyst performance by integrating statistical methods into protein engineering
Appl. Environ. Microbiol.
76
6397-6403
2010
Pseudomonas mendocina (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2), Pseudomonas mendocina KR1 (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2)
Manually annotated by BRENDA team
Bouhajja, E.; McGuire, M.; Liles, M.R.; Bataille, G.; Agathos, S.N.; George, I.F.
Identification of novel toluene monooxygenase genes in a hydrocarbon-polluted sediment using sequence- and function-based screening of metagenomic libraries
Appl. Microbiol. Biotechnol.
101
797-808
2017
uncultured bacterium
Manually annotated by BRENDA team
Tao, Y.; Bentley, W.E.; Wood, T.K.
Phenol and 2-naphthol production by toluene 4-monooxygenases using an aqueous/dioctyl phthalate system
Appl. Microbiol. Biotechnol.
68
614-621
2005
Pseudomonas mendocina (Q00456), Pseudomonas mendocina KR1 (Q00456), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Pikus, J.D.; Studts, J.M.; Achim, C.; Kauffmann, K.E.; Muenck, E.; Steffan, R.J.; McClay, K.; Fox, B.G.
Recombinant toluene-4-monooxygenase: catalytic and Moessbauer studies of the purified diiron and rieske components of a four-protein complex
Biochemistry
35
9106-9119
1996
Pseudomonas mendocina (Q00456 and Q00457 and Q00460 and Q00458 and Q00459), Pseudomonas mendocina, Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460 and Q00458 and Q00459)
Manually annotated by BRENDA team
Pikus, J.D.; Studts, J.M.; McClay, K.; Steffan, R.J.; Fox, B.G.
Changes in the regiospecificity of aromatic hydroxylation produced by active site engineering in the diiron enzyme toluene 4-monooxygenase
Biochemistry
36
9283-9289
1997
Pseudomonas mendocina (Q00456), Pseudomonas mendocina KR1 (Q00456), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Xia, B.; Pikus, J.D.; Xia, W.; McClay, K.; Steffan, R.J.; Chae, Y.K.; Westler, W.M.; Markley, J.L.; Fox, B.G.
Detection and classification of hyperfine-shifted 1H, 2H, and 15N resonances of the Rieske ferredoxin component of toluene 4-monooxygenase
Biochemistry
38
727-739
1999
Pseudomonas mendocina (Q00458), Pseudomonas mendocina KR1 (Q00458), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Pikus, J.D.; Mitchell, K.H.; Studts, J.M.; McClay, K.; Steffan, R.J.; Fox, B.G.
Threonine 201 in the diiron enzyme toluene 4-monooxygenase is not required for catalysis
Biochemistry
39
791-799
2000
Pseudomonas mendocina (Q00456), Pseudomonas mendocina KR1 (Q00456), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Hemmi, H.; Studts, J.M.; Chae, Y.K.; Song, J.; Markley, J.L.; Fox, B.G.
Solution structure of the toluene 4-monooxygenase effector protein (T4moD)
Biochemistry
40
3512-3524
2001
Pseudomonas mendocina (Q00459), Pseudomonas mendocina, Pseudomonas mendocina KR1 (Q00459)
Manually annotated by BRENDA team
Moe, L.A.; Hu, Z.; Deng, D.; Austin, R.N.; Groves, J.T.; Fox, B.G.
Remarkable aliphatic hydroxylation by the diiron enzyme toluene 4-monooxygenase in reactions with radical or cation diagnostic probes norcarane, 1,1-dimethylcyclopropane, and 1,1-diethylcyclopropane
Biochemistry
43
15688-15701
2004
Pseudomonas mendocina (Q00456 and Q00457 and Q00460), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460)
Manually annotated by BRENDA team
Lountos, G.T.; Mitchell, K.H.; Studts, J.M.; Fox, B.G.; Orville, A.M.
Crystal structures and functional studies of T4moD, the toluene 4-monooxygenase catalytic effector protein
Biochemistry
44
7131-7142
2005
Pseudomonas mendocina (Q00459)
Manually annotated by BRENDA team
Moe, L.A.; McMartin, L.A.; Fox, B.G.
Component interactions and implications for complex formation in the multicomponent toluene 4-monooxygenase
Biochemistry
45
5478-5485
2006
Pseudomonas mendocina (Q00456 and Q00457 and Q00460 and Q00458 and Q00459), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460 and Q00458 and Q00459)
Manually annotated by BRENDA team
Elsen, N.L.; Bailey, L.J.; Hauser, A.D.; Fox, B.G.
Role for threonine 201 in the catalytic cycle of the soluble diiron hydroxylase toluene 4-monooxygenase
Biochemistry
48
3838-3846
2009
Pseudomonas mendocina (Q00456), Pseudomonas mendocina KR1 (Q00456)
Manually annotated by BRENDA team
Bailey, L.J.; Acheson, J.F.; McCoy, J.G.; Elsen, N.L.; Phillips, G.N.; Fox, B.G.
Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase
Biochemistry
51
1101-1113
2012
Pseudomonas mendocina (Q00456 and Q00457 and Q00460 and Q00459), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460 and Q00459)
Manually annotated by BRENDA team
Acheson, J.F.; Moseson, H.; Fox, B.G.
Structure of T4moF, the toluene 4-monooxygenase ferredoxin oxidoreductase
Biochemistry
54
5980-5988
2015
Pseudomonas mendocina (Q03304), Pseudomonas mendocina KR1 (Q03304)
Manually annotated by BRENDA team
Nolan, L.C.; OConnor, K.E.
Use of Pseudomonas mendocina, or recombinant Escherichia coli cells expressing toluene-4-monooxygenase, and a cell-free tyrosinase for the synthesis of 4-fluorocatechol from fluorobenzene
Biotechnol. Lett.
29
1045-1050
2007
Pseudomonas mendocina (Q00456 and Q00457 and Q00460 and Q00458 and Q00459), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460 and Q00458 and Q00459)
Manually annotated by BRENDA team
Brouk, M.; Fishman, A.
Protein engineering of toluene monooxygenases for synthesis of hydroxytyrosol
Food Chem.
116
114-121
2009
Pseudomonas mendocina (Q00456 and Q00457 and Q00460), Burkholderia cepacia (Q9ANX2), Burkholderia cepacia G4 (Q9ANX2), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460)
Manually annotated by BRENDA team
Whited, G.M.; Gibson, D.T.
Toluene-4-monooxygenase, a three-component enzyme system that catalyzes the oxidation of toluene to p-cresol in Pseudomonas mendocina KR1
J. Bacteriol.
173
3010-3016
1991
Pseudomonas mendocina (Q00456 and Q00457 and Q00460 and Q00458 and Q00459), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460 and Q00458 and Q00459)
Manually annotated by BRENDA team
Yen, K.M.; Karl, M.R.; Blatt, L.M.; Simon, M.J.; Winter, R.B.; Fausset, P.R.; Lu, H.S.; Harcourt, A.A.; Chen, K.K.
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase
J. Bacteriol.
173
5315-5327
1991
Pseudomonas mendocina (Q00456 and Q00457 and Q00458 and Q00459 and Q00458), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00458 and Q00459 and Q00458)
Manually annotated by BRENDA team
Yen, K.M.; Karl, M.R.
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase
J. Bacteriol.
174
7253-7261
1992
Pseudomonas mendocina (Q03304), Pseudomonas mendocina KR1 (Q03304)
Manually annotated by BRENDA team
Tao, Y.; Fishman, A.; Bentley, W.E.; Wood, T.K.
Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone
J. Bacteriol.
186
4705-4713
2004
Pseudomonas mendocina (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2), Pseudomonas mendocina KR1 (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2), Pseudomonas mendocina KR1
Manually annotated by BRENDA team
Keener, W.K.; Watwood, M.E.; Schaller, K.D.; Walton, M.R.; Partin, J.K.; Smith, W.A.; Clingenpeel, S.R.
Use of selective inhibitors and chromogenic substrates to differentiate bacteria based on toluene oxygenase activity
J. Microbiol. Methods
46
171-185
2001
Burkholderia cepacia, Burkholderia cepacia G4
Manually annotated by BRENDA team
Brouk, M.; Derry, N.; Shainsky, J.; Zelas, Z.; Boyko, Y.; Dabush, K.; Fishman, A.
The influence of key residues in the tunnel entrance and the active site on activity and selectivity of toluene-4-monooxygenase
J. Mol. Catal. B
66
72-80
2010
Pseudomonas mendocina (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2), Pseudomonas mendocina KR1 (Q6Q8Q7 and Q6Q8Q6 and Q6Q8Q5 and Q6Q8Q4 and Q6Q8Q3 and Q6Q8Q2)
-
Manually annotated by BRENDA team
Loprasert, S.
Cloning of toluene 4-monooxygenase genes and application of two-phase system to the production of the anticancer agent, indirubin
Mol. Biotechnol.
57
720-726
2015
Pseudomonas sp. M4 (A0A0D3QM77 and A0A0D3QME2 and A0A0D3QLU4 and A0A0D3QM47 and A0A0D3QMJ7 and A0A0D3QM80)
Manually annotated by BRENDA team
Acheson, J.; Bailey, L.; Elsen, N.; Fox, B.
Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system
Nat. Commun.
5
5009
2014
Pseudomonas mendocina (Q00456)
Manually annotated by BRENDA team
Studts, J.M.; Mitchell, K.H.; Pikus, J.D.; McClay, K.; Steffan, R.J.; Fox, B.G.
Optimized expression and purification of toluene 4-monooxygenase hydroxylase
Protein Expr. Purif.
20
58-65
2000
Pseudomonas mendocina (Q00456 and Q00457 and Q00460), Pseudomonas mendocina KR1 (Q00456 and Q00457 and Q00460)
Manually annotated by BRENDA team