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1.14.13.232: 6-methylpretetramide 4-monooxygenase

This is an abbreviated version!
For detailed information about 6-methylpretetramide 4-monooxygenase, go to the full flat file.

Reaction

6-methylpretetramide
+
NADPH
+
H+
+
O2
=
4-hydroxy-6-methylpretetramide
+
NADP+
+
H2O

Synonyms

OxyE, oxyL

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.232 6-methylpretetramide 4-monooxygenase

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Resultsin table
43AA Sequence
1Cloned(Commentary)
2Cofactor
6General Information
8Organism
5Pathway
1Reaction
6Reference
4Substrates and Products (Substrate)
5Synonyms
1Systematic Name

Systematic Name

Systematic Name on EC 1.14.13.232 - 6-methylpretetramide 4-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating)
The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction - OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD.