1.14.13.232: 6-methylpretetramide 4-monooxygenase
This is an abbreviated version!
For detailed information about 6-methylpretetramide 4-monooxygenase, go to the full flat file.
Reaction
Synonyms
OxyE, oxyL
ECTree
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General Information
General Information on EC 1.14.13.232 - 6-methylpretetramide 4-monooxygenase
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physiological function
a gene disruption mutant reveals the complete disappearance of oxytetracycline, with the concomitant appearance of a predominant glycoside metabolite derived from 4-hydroxy-6-methylpretetramid
physiological function
OxyE plays a nonessential, but important role in oxytetracycline biosynthesis by serving as a efficient C-4 hydroxylase. A gene disruption mutant produces only about 50% of the oxytetracycline found in wild-type, and additionally synthesizes a glycoside derivative of 6-methylpretetramide
physiological function
OxyL is a NADPH-dependent dioxygenase that hydroxylates 6-methylpretetramide at both C12a and C4 positions
physiological function
-
a gene disruption mutant reveals the complete disappearance of oxytetracycline, with the concomitant appearance of a predominant glycoside metabolite derived from 4-hydroxy-6-methylpretetramid
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physiological function
-
OxyL is a NADPH-dependent dioxygenase that hydroxylates 6-methylpretetramide at both C12a and C4 positions
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physiological function
-
OxyE plays a nonessential, but important role in oxytetracycline biosynthesis by serving as a efficient C-4 hydroxylase. A gene disruption mutant produces only about 50% of the oxytetracycline found in wild-type, and additionally synthesizes a glycoside derivative of 6-methylpretetramide
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