1.14.13.23: 3-hydroxybenzoate 4-monooxygenase
This is an abbreviated version!
For detailed information about 3-hydroxybenzoate 4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.23
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1.14.13.23
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phenol
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4-hydroxybenzoate
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hydroxylases
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testosteroni
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fad
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gentisate
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comamonas
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mobility-shift
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salicylate
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repressor
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regioselective
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flavoprotein
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unbound
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mobr
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dioxygenase
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protocatechuate
- 1.14.13.23
- phenol
- 4-hydroxybenzoate
- hydroxylases
- testosteroni
- fad
- gentisate
-
comamonas
-
mobility-shift
- salicylate
- repressor
-
regioselective
- flavoprotein
-
unbound
- mobr
- dioxygenase
- protocatechuate
Reaction
Synonyms
3-hydroxybenzoate 4-hydroxylase, 3-hydroxybenzoate hydroxylase, 3-hydroxybenzoate-4-hydroxylase, 3HB4H, EC 1.14.99.13, FAD-dependent 4-hydroxybenzoate hydroxylase, m-hydroxybenzoate hydroxylase, MHBH, MobA, oxygenase, 3-hydroxybenzoate 4-mono-
ECTree
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General Information
General Information on EC 1.14.13.23 - 3-hydroxybenzoate 4-monooxygenase
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evolution
phylogenetic analysis of FAD-dependent 4-hydroxybenzoate hydroxylases and 3-hydroxybenzoate 4-hydroxylase, phylogenetic analysis and tree, overview. Enzyme structure analysis and comparisons (PDB ID pdb: 2dkh). Enzyme 3HB4H is missing a flexible loop, which is involved in flavin movement and closing-off the active site. In 3HB4H, the conserved tyrosine 222 makes a hydrogen bond with the hydroxyl group of the phenolic substrate, substrate binding pocket and structure-function analysis, homology modeling, overview. Residues Asp75 and Tyr271 might enhance the electron donating capacity of the hydroxyl group of 3-hydroxybenzoate (3-HB). The carboxyl group of 3-HB preferentially interacts with the side chains of His135 and Lys247. This ionic interaction is proposed to determine the orientation of bound substrate
metabolism
additional information
FAD-dependent hydroxybenzoate hydroxylase enzymes structure comparisons, overview
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the enzyme is involved in the degradation of the environmental pollutant 3-chlorobenzoate
metabolism
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the enzyme is involved in the degradation of the environmental pollutant 3-chlorobenzoate
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