1.14.13.22: cyclohexanone monooxygenase

This is an abbreviated version!
For detailed information about cyclohexanone monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.22

Reaction

cyclohexanone
+
NADPH
+
H+
+
O2
=
hexano-6-lactone
+
NADP+
+
H2O

Synonyms

Bpro_556, CAMO, CHMO, ChnB, chnB protein, chnB1 protein, CHXON, CMO, cycloalkaone monooxygenase, cyclohexanone 1, 2-mono-oxygenase, cyclohexanone mono-oxygenase, cyclohexanone monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming), oxygenase, cyclohexanone mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.22 cyclohexanone monooxygenase

pH Range

pH Range on EC 1.14.13.22 - cyclohexanone monooxygenase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 10.5
-
no activity below pH 5.5 and above pH 10.5 at 30°C
6 - 10.5
-
pH 6.0: about 40% of activity maximum with isozymes type 1 and type 2, pH 10.5: about 10% of activity maximum with isozyme type 1, about 60% of activity maximum with isozyme type 2
6 - 11
-
at pH 6.0 and 11.0: about 10% of activity maximum
7 - 8.5
70% of maximal activity at pH 7.0 within this range, His-tagged recombinant enzyme