1.14.13.22: cyclohexanone monooxygenase

This is an abbreviated version!
For detailed information about cyclohexanone monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.22

Reaction

cyclohexanone
+
NADPH
+
H+
+
O2
=
hexano-6-lactone
+
NADP+
+
H2O

Synonyms

Bpro_556, CAMO, CHMO, ChnB, chnB protein, chnB1 protein, CHXON, CMO, cycloalkaone monooxygenase, cyclohexanone 1, 2-mono-oxygenase, cyclohexanone mono-oxygenase, cyclohexanone monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming), oxygenase, cyclohexanone mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.22 cyclohexanone monooxygenase

Turnover Number

Turnover Number on EC 1.14.13.22 - cyclohexanone monooxygenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.16 - 0.47
2-butanone
4.5
2-hydroxycyclobutanone
pH 8.0, 25°C
8.4
2-methylcyclohexyl boronic acid
-
-
0.73
2-phenylcyclohexanone
pH 8.0, 25°C
0.1 - 0.4
acetophenone
2 - 13.4
bicyclo[3.2.0]hept-2-en-6-one
0.683
cis-hex-2-enyl phenyl selenide
-
-
2 - 6.8
Cyclobutanone
4.3
Cycloheptanone
pH 8.0, 25°C
2 - 57.4
cyclohexanone
0.68
Cyclooctanone
pH 8.0, 25°C
1 - 5.9
Cyclopentanone
0.24
delta-thiovalerolactone
-
substrate inactivates enzyme after a few turnovers
0.227
epsilon-thiocaprolactone
-
substrate inactivates enzyme after a few turnovers
2.38
ethylene monothiocarbonate
-
substrate inactivates enzyme after a few turnovers
0.683
gamma-thiobutyrolactone
-
substrate inactivates enzyme after a few turnovers
9.75
phenyl propargyl selenide
-
-
1
phenylacetone
2 - 3
thioanisole
0.917
trans-hex-2-enyl phenyl selenide
-
-
additional information
additional information
-