1.14.13.22: cyclohexanone monooxygenase

This is an abbreviated version!
For detailed information about cyclohexanone monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.22

Reaction

cyclohexanone
+
NADPH
+
H+
+
O2
=
hexano-6-lactone
+
NADP+
+
H2O

Synonyms

Bpro_556, CAMO, CHMO, ChnB, chnB protein, chnB1 protein, CHXON, CMO, cycloalkaone monooxygenase, cyclohexanone 1, 2-mono-oxygenase, cyclohexanone mono-oxygenase, cyclohexanone monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming), oxygenase, cyclohexanone mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.22 cyclohexanone monooxygenase

KM Value

KM Value on EC 1.14.13.22 - cyclohexanone monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
(+)-Camphor
-
-
0.045
1,3-dithiane
-
pH 8.6, 25°C
0.33
1-Phenyl-2-propanone
-
-
0.5
2-butanone
-
pH 7.0, 25°C
0.12
2-hydroxycyclobutanone
pH 8.0, 25°C
0.0093 - 0.0112
2-Hydroxycyclohexanone
0.012
2-methylcyclohexanone
-
-
0.07
2-methylcyclohexyl boronic acid
-
-
0.35
2-Phenyl-1-ethanal
-
-
0.33
2-phenylcyclohexanone
pH 8.0, 25°C
0.01
3-thiacyclohexanone
-
substrate inactivates enzyme after a few turnovers
0.39
4-Hydroxycyclohexanone
-
-
0.009 - 0.016
4-methylcyclohexanone
0.021
4-thiacyclohexanone
-
-
5 - 13
acetophenone
0.0007 - 0.0014
bicyclo[3.2.0]hept-2-en-6-one
0.025
Butanal
-
-
0.0096
cis-hex-2-enyl phenyl selenide
-
-
0.0035
Cuprizone
-
-
0.007
Cyclobutanone
pH 8.0, 25°C
0.2 - 0.88
Cycloheptanone
0.143 - 0.17
Cyclohexan-1,2-dione
0.19
Cyclohexan-1,4-dione
-
-
0.00048 - 0.04
cyclohexanone
1.03 - 1.8
Cyclooctanone
0.02 - 4.66
Cyclopentanone
0.64
dihydrocarvone
-
-
0.22
ethyl p-tolyl sulfide
-
-
2.5
Iodide
-
-
0.009
n-Butylboronic acid
-
-
0.0025
n-Octylboronic acid
-
-
0.006 - 0.02
NADPH
0.14
Norcamphor
-
-
0.1
O2
-
below
0.03
Phenyl allyl selenide
-
-
0.11
Phenyl allyl sulfide
-
-
0.044
Phenyl methyl selenide
-
-
0.128
phenyl propargyl selenide
-
-
0.2 - 3
phenylacetone
0.043
phenylboronic acid
-
-
0.024
Thiane
0.178
Thiane sulfoxide
-
-
1
thioanisole
-
pH 7.0, 25°C
0.0068
trans-hex-2-enyl phenyl selenide
-
-
0.36
triethyl phosphite
-
-
additional information
additional information
-