1.14.13.215: protoasukamycin 4-monooxygenase
This is an abbreviated version!
For detailed information about protoasukamycin 4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.215
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1.14.13.215
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epoxidized
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zeaxanthin
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drought
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xanthophyll
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epoxidase
- 1.14.13.215
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epoxidized
- zeaxanthin
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drought
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xanthophyll
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epoxidase
Reaction
Synonyms
asuE1, flavin-dependent protoasukamycin hydroxylase, protoasukamycin 4-hydroxylase
ECTree
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General Information
General Information on EC 1.14.13.215 - protoasukamycin 4-monooxygenase
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evolution
malfunction
metabolism
enzyme AsuE1 belongs to the family of single-component monooxygenases: a single enzyme catalyzes both the reduction of flavin by NADPH, and the hydroxylation using molecular oxygen and reduced flavin cofactor
evolution
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enzyme AsuE1 belongs to the family of single-component monooxygenases: a single enzyme catalyzes both the reduction of flavin by NADPH, and the hydroxylation using molecular oxygen and reduced flavin cofactor
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disruption of asuE2 significantly decreases the yield of asukamycin and results in the accumulation of protoasukamycin
malfunction
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disruption of asuE2 significantly decreases the yield of asukamycin and results in the accumulation of protoasukamycin
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AsuE1 and AsuE3, both single-component flavin-dependent monooxygenases, catalyze the exquisite regio- and enantiospecific postpolyketide synthase (PKS) assembly oxygenations. AsuE1 installs a hydroxyl group on the 3,4-AHB ring to form a 4-hydroxyquinone moiety, which is epoxidized by AsuE3 to yield the epoxyquinone functionality. Despite being a single-component monooxygenase, AsuE1 activity is elicited by AsuE2, a pathway-specific flavin reductase
metabolism
in the asukamycin metabolism, enzymes AsuE1 and AsuE2 catalyze the conversion of protoasukamycin to 4-hydroxyprotoasukamycin, which is epoxidized at C5-C6 by enzyme AsuE3 to the final product, asukamycin. Synthesis and structures of asukamycin and related metabolites, overview
metabolism
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AsuE1 and AsuE3, both single-component flavin-dependent monooxygenases, catalyze the exquisite regio- and enantiospecific postpolyketide synthase (PKS) assembly oxygenations. AsuE1 installs a hydroxyl group on the 3,4-AHB ring to form a 4-hydroxyquinone moiety, which is epoxidized by AsuE3 to yield the epoxyquinone functionality. Despite being a single-component monooxygenase, AsuE1 activity is elicited by AsuE2, a pathway-specific flavin reductase
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