1.14.13.196: L-ornithine N5-monooxygenase [NAD(P)H]

This is an abbreviated version!
For detailed information about L-ornithine N5-monooxygenase [NAD(P)H], go to the full flat file.

Reaction

L-ornithine
+
NAD(P)H
+
H+
+
O2
=
N5-hydroxy-L-ornithine
+
NAD(P)+
+
H2O

Synonyms

abachelin monooxygenase, AfSidA, AMO, SidA, siderophore A

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.196 L-ornithine N5-monooxygenase [NAD(P)H]

Substrates Products

Substrates Products on EC 1.14.13.196 - L-ornithine N5-monooxygenase [NAD(P)H]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-ornithine + NAD(P)H + H+ + O2
N5-hydroxy-L-ornithine + NAD(P)+ + H2O
show the reaction diagram
Q5SE95
the enzyme catalyzes the hydroxylation of L-ornithine in ferrichrome biosynthesis
-
-
?
L-ornithine + NADH + H+ + O2
N5-hydroxy-L-ornithine + NAD+ + H2O
show the reaction diagram
L-ornithine + NADPH + H+ + O2
N5-hydroxy-L-ornithine + NADP+ + H2O
show the reaction diagram
additional information
?
-
-
holo (FAD-bound) and apo (FAD-free) forms of the enzyme hydroxylate ornithine. No activity with L-lysine. The enzyme displays very low selectivity for the reduced nicotinamide coenzyme
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-
-