1.14.13.187: L-evernosamine nitrososynthase

This is an abbreviated version!
For detailed information about L-evernosamine nitrososynthase, go to the full flat file.

Word Map on EC 1.14.13.187

Reaction

dTDP-beta-L-evernosamine
+ 2 NADPH + 2 H+ + 2 O2 =
dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose
+ 2 NADP+ + 3 H2O

Synonyms

DnmZ, nitrososynthase, ORF36

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.187 L-evernosamine nitrososynthase

Systematic Name

Systematic Name on EC 1.14.13.187 - L-evernosamine nitrososynthase

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SYSTEMATIC NAME
IUBMB Comments
dTDP-beta-L-evernosamine,NADPH:oxygen oxidoreductase (N-hydroxylating)
Requires FAD. Isolated from the bacterium Micromonospora carbonacea var. africana. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin. The reaction was studied using dTDP-beta-L-4-epi-vancosamine (dTDP-4-O-desmethyl-beta-L-evernitrosamine).