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1.14.13.187: L-evernosamine nitrososynthase

This is an abbreviated version!
For detailed information about L-evernosamine nitrososynthase, go to the full flat file.

Word Map on EC 1.14.13.187

Reaction

dTDP-beta-L-evernosamine
+ 2 NADPH + 2 H+ + 2 O2 =
dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose
 + 2 NADP+ + 3 H2O

Synonyms

DnmZ, nitrososynthase, ORF36

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.187 L-evernosamine nitrososynthase

General Information

General Information on EC 1.14.13.187 - L-evernosamine nitrososynthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
in the anthracycline biosynthetic pathway, the enzyme's specific role involves the synthesis of the seven-carbon acetal moiety attached to C4 of l-daunosamine observed in the anthracycline baumycin
physiological function
DnmZ is an N-hydroxylating flavin monooxygenase and a nitrososynthase that catalyzes the oxidation of the exocyclic amine of the sugar nucleotide dTDP-L-epi-vancosamine to its nitroso form. Its specific role in the anthracycline biosynthetic pathway involves the synthesis of the seven-carbon acetal moiety attached to C4 of l-daunosamine observed in the anthracycline baumycin
additional information