1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.

Reaction

Synonyms

6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, HSP monooxygenase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD, W7K_00670

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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Results	in table
1	Activating Compound
90	AA Sequence
4	Application
5	Cloned(Commentary)
15	Cofactor
2	Expression
20	General Information
23	Inhibitors
2	kcat/KM [mM/s]
11	KM Value [mM]
3	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
2	PDB ID
7	pH Optimum
1	pH Range
2	pH Stability
2	Protein Variants
5	Purification (Commentary)
3	Reaction
17	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
24	Substrates and Products (Substrate)
7	Subunits
40	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)

The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].