1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.163

Reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate
+ 2 NADH + 2 H+ +
O2
=
2,5-dihydroxypyridine
 +
succinate semialdehyde
 + 2 NAD+ +
H2O

Synonyms

6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].