1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.163

Reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate
+ 2 NADH + 2 H+ +
O2
=
2,5-dihydroxypyridine
+
succinate semialdehyde
+ 2 NAD+ +
H2O

Synonyms

6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase

Specific Activity

Specific Activity on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.8
pH 8.0, 25C
5.1
-
purified native enzyme, pH 8.5, 30C
10.3
W8E0Y0
purified native enzyme, pH 8.0, 30C
18.8
W8E0Y0
purified recombinant enzyme, pH 8.0, 30C
31.8
-
purified recombinant His-tagged enzyme, pH 8.5, 30C