1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.163

Reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate
+ 2 NADH + 2 H+ +
O2
=
2,5-dihydroxypyridine
+
succinate semialdehyde
+ 2 NAD+ +
H2O

Synonyms

6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetone
-
inhibits at 20% v/v
Cd2+
strong inhibition
Chloroform
-
inhibits at 20% v/v
Co2+
-
inhibits at 5 mM
dimethylformamide
-
inhibits at 20% v/v
DMSO
-
inhibits slightly by 10% at 20% v/v
EDTA
-
inhibits 15-20% at 0.5-5 mM
Fe2+
-
inhibits at 5 mM
formaldehyde
-
inhibits at 20% v/v
methanol
-
inhibits at 20% v/v
Mg2+
-
slight inhibition
Mn2+
-
slight inhibition
Span-20
-
at 1% w/v by over 50%
SPAN-40
-
at 1% w/v by over 50%
Toluene
-
inhibits at 20% v/v
Triton X-100
-
at 1% w/v by over 50%
additional information
-
no inhibition by Twen-20, Tween-40, and Tween-80 at 1% w/v
-