1.14.13.146: taxoid 14beta-hydroxylase

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For detailed information about taxoid 14beta-hydroxylase, go to the full flat file.

Reaction

Synonyms

cytochrome P450 taxoid 14beta-hydroxylase, taxoid 14beta-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.146 taxoid 14beta-hydroxylase

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Results	in table
2	AA Sequence
2	Application
2	Cloned(Commentary)
2	Cofactor
2	KM Value [mM]
1	Localization
1	Molecular Weight [Da]
2	Organism
5	Pathway
1	pH Optimum
1	Reaction
2	Reference
3	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
1	Systematic Name

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Application on EC 1.14.13.146 - taxoid 14beta-hydroxylase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

Taxus chinensis

-

an antisense suppression approach, repressing the expression of the taxoid 14beta-hydroxlyase gene in yew cell cultures, is useful to inhibit the expression of other important genes in side-route of Taxol pathway and this may diverts the flow of taxadiene mainly towards Taxol

717056

medicine

Taxus cuspidata

Q84KI1

manipulation of the hydroxylase gene can permit redirection of the pathway to increase flux toward taxol and can allow the preparation of 13alpha,14beta-hydroxy taxoids as new therapeutic agents

717152