1.14.13.130: pyrrole-2-carboxylate monooxygenase
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For detailed information about pyrrole-2-carboxylate monooxygenase, go to the full flat file.
Reaction
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Substrates Products
Substrates Products on EC 1.14.13.130 - pyrrole-2-carboxylate monooxygenase
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REACTION DIAGRAM
additional information
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no enzymatic activity is detected with the analogous aromatic heterocyclic compounds furan-2-carboxylate and furan-3-carboxylate, and thiophene-2-carboxylate and thiophene-3-carboxylate (0.25 mM). Pyrrole, proline, indole, and indole-2-carboxylate (each 0.25 mM) do not serve as a substrate or effector of NADH oxidation for pyrrole-2-carboxylate monooxygenase. Chlorinated phenols and 4-hydroxyphenylacetate, which are substrates for the structurally related two-component flavin aromatic monooxygenases isolated from different sources, do not affect NADH oxidation or oxygen consumption catalyzed by pyrrole-2-carboxylate monooxygenase
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5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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the enzyme initiates the degradation of pyrrole-2-carboxylate. Growth on pyrrole-2-carboxylate as the sole source of carbon, nitrogen and energy
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pyrrole-2-carboxylate + NADH + H+ + O2
5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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no activity with NADPH. Narrow substrate specificity. Besides pyrrole-2-carboxylate, only pyrrole, pyrrole-2-aldehyde, and indole-2-carboxylate stimulate the oxygen consumption at a very low rate
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pyrrole-2-carboxylate + NADH + H+ + O2
5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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the enzyme initiates the degradation of pyrrole-2-carboxylate. Growth on pyrrole-2-carboxylate as the sole source of carbon, nitrogen and energy
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pyrrole-2-carboxylate + NADH + H+ + O2
5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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no activity with NADPH. Narrow substrate specificity. Besides pyrrole-2-carboxylate, only pyrrole, pyrrole-2-aldehyde, and indole-2-carboxylate stimulate the oxygen consumption at a very low rate
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pyrrole-2-carboxylate + NADH + H+ + O2
5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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no activity with NADPH
the product is unstable. A conversion of 5-hydroxypyrrole-2-carboxylate to 2-oxoglutarate seems to be possible by spontaneous and/or enzyme catayzed hydrolytic reactions
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pyrrole-2-carboxylate + NADH + H+ + O2
5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
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the enzyme initiates the degradation of pyrrole-2-carboxylate. Growth on pyrrole-2-carboxylate as the sole source of carbon, nitrogen and energy
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