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1.14.13.114: 6-hydroxynicotinate 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxynicotinate 3-monooxygenase, go to the full flat file.

Reaction

6-Hydroxynicotinate
+
NADH
 +
H+
 +
O2
=
2,5-dihydroxypyridine
 +
NAD+
 +
H2O
 +
CO2

Synonyms

6-hydroxynicotinic acid 3-monooxygenase, 6HNA monooxygenase, BB1770, BbNicC, NicC, PpNicC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.114 6-hydroxynicotinate 3-monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.114 - 6-hydroxynicotinate 3-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
1 mM, complete inhibition
6-hydroxynicotinaldehyde
competitive inhibition with respect to 6-hydroxynicotinate is weak
Ag2SO4
-
1 mM, complete inhibition
CuCl2
-
1 mM, complete inhibition
HgCl2
-
1 mM, complete inhibition
methylmethanethiosulfonate
-
N-ethylmaleimide
-
1 mM, 69% inhibition
nicotinate
-
potent competitive inhibitor
p-chloromercuribenzoate
-
1 mM, complete inhibition
additional information
-
no significant effect on enzyme activity is found with metal-chelating agents such o-phenanthroline, 8-hydroxyquinoline, EDTA, disodium 4,5-dihydroxy-m-benzenedisulfonate, fluoride and azide, and other compounds such as KCl, LiCl, NaCl, BaCl2, CaCl2, MnCl2, MgCl2, PbCl2, ZnCl2, CoCl2, SnCl2, FeSO4, FeCl3, NiCl2, CdCl2, AlCl3, iodoacetic acid, hydroxylamine, phenylhydrazine, semicarbazide, cysteamine, alpha,alpha'-dipyridyl and urea
-