1.14.13.113: FAD-dependent urate hydroxylase
This is an abbreviated version!
For detailed information about FAD-dependent urate hydroxylase, go to the full flat file.
Reaction
Synonyms
FAD-dependent urate oxidase, flavin adenine dinucleotide-dependent urate oxidase, HpxO, HpxO enzyme, HpyO, urate hydroxylase, XCC0279
ECTree
1.14.13.113 FAD-dependent urate hydroxylaseAdvanced search results
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Engineering on EC 1.14.13.113 - FAD-dependent urate hydroxylase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
R204Q
Y216F
R204Q
Y216F
R204Q
variant results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation. This suggests that Arg204 facilitates the deprotonation of uric acid, activating it for the oxygen transfer
R204Q
the mutation leading to strongly decreased activity results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation
Y216F
the mutant shows decreased activity compared to the wild type enzyme
R204Q
-
variant results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation. This suggests that Arg204 facilitates the deprotonation of uric acid, activating it for the oxygen transfer
-
R204Q
-
the mutation leading to strongly decreased activity results in the uncoupling of nicotinamide adenine dinucleotide oxidation from uric acid hydroxylation
-
Y216F
-
the mutant shows decreased activity compared to the wild type enzyme
-
