1.14.12.24: 2,4-dinitrotoluene dioxygenase

This is an abbreviated version!
For detailed information about 2,4-dinitrotoluene dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.24

1.14.12.24

burkholderia

4-methyl-5-nitrocatechol

cepacia

monooxygenase

naphthalene

2-nitrotoluene

fission

dinitrotoluenes

sphingomonas

nitroaromatic

extradiol

nahac

vitreoscilla

regiospecificity

enantiomeric

priority

Reaction

Synonyms

2,4-dinitrotoluene dioxygenase, 2,4-DNT dioxygenase, 2,4-DNTDO, DDO, DNT dioxygenase, dntA, DntAc, DNTDO

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

1.14.12.24 2,4-dinitrotoluene dioxygenase

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Results	in table
11	Activating Compound
2	AA Sequence
8	Cloned(Commentary)
8	Cofactor
2	General Information
6	Inhibitors
3	KM Value [mM]
2	Localization
1	Metals/Ions
4	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
89	Organism
3	Pathway
1	pH Optimum
1	pH Range
20	Protein Variants
2	Purification (Commentary)
1	Reaction
31	Reference
5	Specific Activity [micromol/min/mg]
122	Substrates and Products (Substrate)
4	Subunits
36	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.14.12.24 - 2,4-dinitrotoluene dioxygenase

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2,4-dinitrotoluene,NADH:oxygen oxidoreductase (4,5-hydroxylating, nitrite-releasing)

This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It does not act on nitrobenzene. cf. EC 1.14.12.23, nitroarene dioxygenase.