1.14.12.12: naphthalene 1,2-dioxygenase

This is an abbreviated version!
For detailed information about naphthalene 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.12

1.14.12.12

putida

polycyclic

bioremediation

rieske

toluene

phenanthrene

dioxygenation

naphthalene-degrading

ring-hydroxylating

dihydroxylation

indigo

pah-degrading

hydrocarbon-degrading

dihydrodiols

cis-dihydrodiols

rieske-type

oil-contaminated

cis-dihydroxylation

parales

2-nitrotoluene

pah-contaminated

acenaphthene

cis-diols

side-on

alpha3beta3

indene

synthesis

Reaction

Synonyms

NAG, NAHA, nahAc, naphthalene 1,2-dioxygenase, naphthalene dioxygenase, naphthalene oxygenase, NDO, oxygenase, naphthalene di-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

1.14.12.12 naphthalene 1,2-dioxygenase

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Results	in table
1	Activating Compound
153	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
44	Cofactor
7	Crystallization (Commentary)
2	General Information
8	General Stability
6	Inhibitors
5	KM Value [mM]
5	Localization
13	Metals/Ions
24	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
113	Organism
6	Pathway
70	PDB ID
5	pH Optimum
43	Protein Variants
15	Purification (Commentary)
5	Reaction
5	Reaction Type
77	Reference
5	Specific Activity [micromol/min/mg]
3	Storage Stability
224	Substrates and Products (Substrate)
16	Subunits
38	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.12.12 - naphthalene 1,2-dioxygenase

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naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)

This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons [5]. This enzyme comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3, ferredoxin---NAD+ reductase), an iron-sulfur oxygenase, and ferredoxin. Requires Fe2+.