1.14.12.11: toluene dioxygenase

This is an abbreviated version!
For detailed information about toluene dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.11

Reaction

Toluene
+
NADH
+
H+
+
O2
=
(1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol
+
NAD+

Synonyms

ISPTOD, ISPTOL, More, oxygenase, toluene 2,3-di-, oxygenaseTOL, TDO, Tod, todC1C2BA, toluene 2,3-dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.11 toluene dioxygenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.12.11 - toluene dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-cresol + NADH + H+ + O2
?
show the reaction diagram
-
activity in strain UV4
-
-
?
3-cresol + NADH + H+ + O2
?
show the reaction diagram
-
activity in strain UV4formation of the corresponding cis-diol and catechol
-
-
?
4-xylene + NADH + H+ + O2
4-xylenol + NAD+ + H2O
show the reaction diagram
-
activity in strain 39/D
-
-
?
benzene + NADH + O2
benzene dihydrodiol + NAD+
show the reaction diagram
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
ethylbenzene + NADH + O2
?
show the reaction diagram
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
indole + NADH + H+ + O2
2,2'-bis(2,3-dihydro-3-oxoindolyliden) + NAD+
show the reaction diagram
-
toluene dioxygenase is ubiquitous in nature and has a broad substrate range, including benzene, toluene, ethylbenzene and xylenes. The organism produces indigo from indole through the activity of TDO
i.e. indigo
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
show the reaction diagram
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
show the reaction diagram
xylene + NADH + O2
?
show the reaction diagram
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
additional information
?
-