1.14.11.B22: ergot alkaloid dioxygenase
This is an abbreviated version!
For detailed information about ergot alkaloid dioxygenase, go to the full flat file.
Reaction
Synonyms
EasH
ECTree
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General Information
General Information on EC 1.14.11.B22 - ergot alkaloid dioxygenase
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metabolism
EasH converts a six-membered enamine intermediate, generated by lavoenzyme EasA from chanocalvine-I aldehyde, to a cyclopropyl group-containing intermediate, which is reduced to cycloclavine by the nicotinamide adenine dinucleotide phosphate-dependent imine reductase EasG
physiological function
EasH is a 2-oxoglutarate-dependent non-heme iron dioxygenase. EasH is a promiscuous and bimodal dioxygenase that catalyzes both the formation of cyclopropyl ring and the asymmetric hydroxylation ergot alkaloids