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1.14.11.B19: [histone H3]-trimethyl-L-lysine56 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine56 demethylase, go to the full flat file.

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine56
+
2-oxoglutarate
+
O2
=
a [histone H3]-N6,N6-dimethyl-L-lysine56
+
succinate
+
formaldehyde
+
CO2

Synonyms

JMJD2D, KDM4DL, KDM4E, lysine-specific demethylase 4E

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.B19 [histone H3]-trimethyl-L-lysine56 demethylase

Reference

Reference on EC 1.14.11.B19 - [histone H3]-trimethyl-L-lysine56 demethylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Colmenares, S.U.; Swenson, J.M.; Langley, S.3.; Kennedy, C.; Costes, S.V.; Karpen, G.H.
Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity
Dev. Cell
42
156-169
2017
Drosophila melanogaster (Q9V333)
Manually annotated by BRENDA team
Jack, A.P.M.; Bussemer, S.; Hahn, M.; Pünzeler, S.; Snyder, M.; Wells, M.; Csankovszki, G.; Solovei, I.; Schotta, G.; Hake, S.B.
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization
PLoS ONE
8
e51765
2013
Homo sapiens (B2RXH2), Mus musculus (Q3U2K5)
Manually annotated by BRENDA team