1.14.11.B19: [histone H3]-trimethyl-L-lysine56 demethylase
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For detailed information about [histone H3]-trimethyl-L-lysine56 demethylase, go to the full flat file.
Reaction
Synonyms
JMJD2D, KDM4DL, KDM4E, lysine-specific demethylase 4E
ECTree
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General Information
General Information on EC 1.14.11.B19 - [histone H3]-trimethyl-L-lysine56 demethylase
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physiological function
KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage
physiological function
overexpression of human KDM4E strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain
physiological function
overexpression of mouse Jmjd2D strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain