1.14.11.8: trimethyllysine dioxygenase

This is an abbreviated version!
For detailed information about trimethyllysine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.8

Reaction

N6,N6,N6-Trimethyl-L-lysine
+
2-oxoglutarate
+
O2
=
(3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine
+
succinate
+
CO2

Synonyms

6-N-trimethyllysine dioxygenase, epsilon-N-trimethyllysine hydroxylase, epsilon-trimethyllysine 2-oxoglutarate dioxygenase, eta-N-trimethyllysine hydroxylase, Nepsilon-trimethyllysine hydroxylase, oxygenase, trimethyllysine di-, TML dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TMLD, TMLH, TMLH-a, TMLH-b, trimethyllysine alpha-ketoglutarate dioxygenase, trimethyllysine hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.8 trimethyllysine dioxygenase

Expression

Expression on EC 1.14.11.8 - trimethyllysine dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
pigs fed a high-lysine diet have lower concentrations of free and total carnitine in plasma, liver, kidney and skeletal muscle than control pigs, and have an increased concentration of trimethyllysine, TML, a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine in muscle, indicating that the conversion of trimethyllysine into gamma-butyrobetaine in muscle is impaired
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