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1.14.11.79: protein-L-histidine (3S)-3-hydroxylase

This is an abbreviated version!
For detailed information about protein-L-histidine (3S)-3-hydroxylase, go to the full flat file.

Reaction

a [protein]-L-histidine
+
2-oxoglutarate
+
O2
=
a [protein]-(3S)-3-hydroxy-L-histidine
+
succinate
+
CO2

Synonyms

C14orf169, MAPJD, MDIG, MINA, MINA53, NO52, NO66, protein histidyl hydroxylase, RIOX1, RIOX2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.79 protein-L-histidine (3S)-3-hydroxylase

Systematic Name

Systematic Name on EC 1.14.11.79 - protein-L-histidine (3S)-3-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
protein-L-histidine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)
The human enzymes encoded by the RIOX1 and RIOX2 genes catalyse the hydroxylation of L-histidine residues in the 60S ribosomal proteins Rpl8 and L27a, respectively. Both proteins contain JmjC and winged helix domains, and both also catalyse histone L-lysine demethylation activities.