1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

Reaction

[procollagen]-L-proline
+
2-oxoglutarate
+
O2
=
[procollagen]-trans-3-hydroxy-L-proline
+
succinate
+
CO2

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.7 procollagen-proline 3-dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoadipate
-
-
2-oxobutyrate
-
-
2-oxpentanoate
-
-
3-oxoglutarate
-
-
adipate
-
-
benzene-1,2-dicarboxylate
-
-
Benzene-1,3-dicarboxylate
-
-
Benzene-1,4-dicarboxylate
-
-
benzoate
-
-
concanavalin A
-
-
-
Glutarate
-
-
laevulinate
-
-
malonate
-
-
Mg2+
-
slight inhibition
Mn2+
-
slight inhibition
oxaloacetate
-
-
poly(L-Pro)
MW 7000-8000 Da; MW 7000-8000 Da
pyridine-2,3-dicarboxylate
-
-
Pyridine-2,4-dicarboxylate
Pyridine-2,5-dicarboxylate
pyridine-2-carboxylate
-
-
pyridine-3,4-dicarboxylate
-
-
pyridine-3,5-dicarboxylate
-
-
pyridine-3-carboxylate
-
-
pyridine-4-carboxylate
-
-
pyruvate
-
-
succinate
-
-