1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase

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For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.

Word Map on EC 1.14.11.68

1.14.11.68

kabuki

chromatin

facial

demethylases

intellectual

pik3ca

arid1a

crebbp

h3k4me3

polycomb

medicine

muscle-invasive

smarca4

k-specific

fat1

gestalt

gsk-j4

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

+ 2 2-oxoglutarate + 2 O2 =

+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase

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22	AA Sequence
8	Application
2	Cloned(Commentary)
1	Crystallization (Commentary)
585	Disease/ Diagnostics
5	Expression
23	General Information
4	Inhibitors
10	Localization
1	Metals/Ions
5	Natural Substrates/ Products (Substrates)
35	Organism
2	Protein Variants
3	Reaction
33	Reference
24	Source Tissue
23	Substrates and Products (Substrate)
32	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase

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[histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase

Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.