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1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.

Word Map on EC 1.14.11.68

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine27
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase

Substrates Products

Substrates Products on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a [histine H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
a [histine H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
?
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2
a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
?
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2
a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
[histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
show the reaction diagram
[histone H3]-N6-methyllysine27 + 2-oxoglutarate + O2
[histone H3]-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
additional information
?
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