1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase
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For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.
Word Map on EC 1.14.11.68
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1.14.11.68
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kabuki
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chromatin
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facial
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demethylases
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intellectual
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pik3ca
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arid1a
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crebbp
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h3k4me3
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polycomb
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medicine
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muscle-invasive
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smarca4
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k-specific
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fat1
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gestalt
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gsk-j4
- 1.14.11.68
-
kabuki
- chromatin
-
facial
- demethylases
-
intellectual
- pik3ca
-
arid1a
- crebbp
-
h3k4me3
-
polycomb
- medicine
-
muscle-invasive
-
smarca4
-
k-specific
- fat1
-
gestalt
- gsk-j4
Reaction
Synonyms
F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY
ECTree
1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylaseAdvanced search results
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Source Tissue on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
expressed in macrophages in response to bacterial products and inflammatory cytokines
neutrophil JMJD3 expression is increased in patients with sepsis
additional information
UTX is selectively excluded from the HOX loci in embryonic stem cells, in which HOX genes are largely silent
at the blastula stage, Jmjd3, Utx and H3K27 methylase Ezh2 show similar expression patterns in the animal cap and marginal zone that give rise to the ectoderm and mesoderm, respectively. The three genes maintain similar expresxadsion patterns in the neural plate, preplacodal ectoderm and axial mesoderm during the gastrula and neurula stages. Later, expression is maintained in the developing brain and cranial sensory tissues, such as the eye and ear, of tailbud embryos
UTX is enriched around the transcription start sites of many HOX genes in primary human fibroblasts
