1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase
This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.
Word Map on EC 1.14.11.68
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1.14.11.68
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kabuki
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chromatin
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facial
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demethylases
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intellectual
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pik3ca
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arid1a
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crebbp
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h3k4me3
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polycomb
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medicine
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muscle-invasive
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smarca4
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k-specific
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fat1
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gestalt
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gsk-j4
- 1.14.11.68
-
kabuki
- chromatin
-
facial
- demethylases
-
intellectual
- pik3ca
-
arid1a
- crebbp
-
h3k4me3
-
polycomb
- medicine
-
muscle-invasive
-
smarca4
-
k-specific
- fat1
-
gestalt
- gsk-j4
Reaction
+ 2 2-oxoglutarate + 2 O2 = + 2 succinate + 2 formaldehyde + 2 CO2
Synonyms
F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY
ECTree
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Inhibitors
Inhibitors on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase
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GSKJ4
inhibitor is active against native and temozolomide-resistant glioblastoma cells, albeit at at a lower effcacy than JIB 04, inhibitor of lysine demethylase KDM5A, EC 1.14.11.67. GSK J4 and JIB 04 strongly synergize and are a potent combination against temozolomide-resistant glioblastoma cells. GSK J4 does not synergize with temozolomide
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both the mRNA and protein levels of mPR3 are significantly reduced compared to controls
GSK-J4
specific inhibitor, application dramatically suppresses Th17 cell differentiation in vitro
GSK-J4
specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits herpes simplex virus HSV-1 reactivation from sensory neurons in vitro; specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits herpes simplex virus HSV-1 reactivation from sensory neurons in vitro