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1.14.11.68: [histone H3]-trimethyl-L-lysine27 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine27 demethylase, go to the full flat file.

Word Map on EC 1.14.11.68

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine27
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

F18E9.5, histone demethylase, jmjd-3.1, JMJD3, KDM6A, Kdm6al, KDM6B, KDM6C, lysine-specific demethylase 6A, lysine-specific demethylase 6B, UTX, UTX1, UTY

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase

Expression

Expression on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
GSK-J4 reduces both the mRNA and protein levels of mPR3 significantly compared to controls
Jmjd3 expression is upregulated at the outset of neural commitment
JMJD3 is upregulated in prostate cancer, and its expression is higher in metastatic prostate cancer
lipopolysaccharide (LPS) induces JMJD3 expression in vitro. Neutrophil JMJD3 expression is increased in patients with sepsis compared to controls
presence of nickel chloride upregulates the expression of H3K27me3 demethylase Jmjd3 in kidney cancer cells, which is accompanied by the reduction in the protein level of H3K27me3