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1.14.11.67: [histone H3]-trimethyl-L-lysine4 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine4 demethylase, go to the full flat file.

Word Map on EC 1.14.11.67

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
+ 3 2-oxoglutarate + 3 O2 =
a [histone H3]-L-lysine4
+ 3 succinate + 3 formaldehyde + 3 CO2

Synonyms

amine oxidase (flavin-containing) domain 1, AOF1, At2g34880, CG33182, CG33185, CG3654, dJARID2, dJARID2/CG3654, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, Fbxl10, GH09982, H3K4 demethylase, H3K4 demethylase lysine-specific demethylase 5A, H3K4 histone demethylase, H3K4me3 demethylase, H3K4me3 histone demethylase, H3K4me3-specific demethylase, H3K4me3/2 histone demethylase, H3K9 trimethyl demethylase, histone 3 lysine 4 demethylase, histone demethylase, histone H3 lysine 4 demethylase, histone H3 lysine-4 demethylase, histone H3-K4 demethylase, histone H3K4 demethylase, histone H3K4-specific demethylase, histone lysine demethylase, histone-H3K4-specific demethylase, Jarid1, Jarid1a, JARID1B, JARID1C, Jarid2, JaridB, Jhd2, Jhdm1b/Kdm2b, JMJ15, JMJ703, JmjC domain histone demethylase, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC+N, JmjC+N histone demethylase, JMJD2A, JMJD2A-tudor, JMJD2B, jumonji AT rich interactive domain 1B, jumonji AT-rich interactive domain 1B, Jumonji demethylase, KDM1, KDM1B, KDM2, KDM5, KDM5A, KDM5B, KDM5b/JARID1b, KDM5C, KDM5D, Lid, little imaginal discs, LSD1, lysine demethylase, lysine demethylase 5b, lysine demethylase 7, lysine-specific demethylase, lysine-specific demethylase 1, lysine-specific demethylase 5A, lysine-specific demethylase 5B, lysine-specific demethylase JMJ703, Lysine-specific demethylase SE14, More, Ndy1, Os03g0151300, PHD finger protein 8, PHF8, PKDM7B, PLU-1, PLU1, RB-binding protein 2, RBP2, RBR-2, retinoblastoma binding protein 2, SE14, SMCX, trimethylated lysine 4 of histone H3 demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase

Source Tissue

Source Tissue on EC 1.14.11.67 - [histone H3]-trimethyl-L-lysine4 demethylase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low KDM5B expression level
Manually annotated by BRENDA team
-
high expression level of JARID1B
Manually annotated by BRENDA team
-
expression in the early epiblast
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
H3-K4 mono-, di-, and tri-methylation in large luteal cells increases as differentiation evolves but remains low in small luteal cells
Manually annotated by BRENDA team
high KDM5B expression level
Manually annotated by BRENDA team
low KDM5B expression level
Manually annotated by BRENDA team
low KDM5B expression level
Manually annotated by BRENDA team
expression of endogenous JARID1A is detected in both undifferentiated MEL cells, and MEL cells undergoing terminal erythroid maturation
Manually annotated by BRENDA team
-
histone H3 lysine 4 demethylase JARID1B is up-regulated in prostate cancer. JARID1B associates with androgen receptor and regulates its transcriptional activity
Manually annotated by BRENDA team
low KDM5B expression level
Manually annotated by BRENDA team
high KDM5B expression level
Manually annotated by BRENDA team
-
Beko cell, spontaneous T-cell lymphoma cell line derived from T-cell receptor beta knockout mice, only KDM5A and KDM5C are expressed
Manually annotated by BRENDA team
high KDM5B expression level
Manually annotated by BRENDA team
additional information