1.14.11.67: [histone H3]-trimethyl-L-lysine4 demethylase
This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine4 demethylase, go to the full flat file.
Word Map on EC 1.14.11.67
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1.14.11.67
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chromatin
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demethylases
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trimethylation
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polycomb
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x-linked
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pluripotency
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ccrcc
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methyltransferases
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intellectual
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self-renewal
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corepressors
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h3k4me2
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chip-seq
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x-inactivation
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histone-modifying
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corest
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prc1
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chromatin-modifying
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lys4
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nanog
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k-specific
- 1.14.11.67
- chromatin
- demethylases
-
trimethylation
-
polycomb
-
x-linked
-
pluripotency
-
ccrcc
- methyltransferases
-
intellectual
-
self-renewal
-
corepressors
-
h3k4me2
-
chip-seq
-
x-inactivation
-
histone-modifying
- corest
- prc1
-
chromatin-modifying
- lys4
-
nanog
-
k-specific
Reaction
Synonyms
amine oxidase (flavin-containing) domain 1, AOF1, At2g34880, CG33182, CG33185, CG3654, dJARID2, dJARID2/CG3654, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, Fbxl10, GH09982, H3K4 demethylase, H3K4 demethylase lysine-specific demethylase 5A, H3K4 histone demethylase, H3K4me3 demethylase, H3K4me3 histone demethylase, H3K4me3-specific demethylase, H3K4me3/2 histone demethylase, H3K9 trimethyl demethylase, histone 3 lysine 4 demethylase, histone demethylase, histone H3 lysine 4 demethylase, histone H3 lysine-4 demethylase, histone H3-K4 demethylase, histone H3K4 demethylase, histone H3K4-specific demethylase, histone lysine demethylase, histone-H3K4-specific demethylase, Jarid1, Jarid1a, JARID1B, JARID1C, Jarid2, JaridB, Jhd2, Jhdm1b/Kdm2b, JMJ15, JMJ703, JmjC domain histone demethylase, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC+N, JmjC+N histone demethylase, JMJD2A, JMJD2A-tudor, JMJD2B, jumonji AT rich interactive domain 1B, jumonji AT-rich interactive domain 1B, Jumonji demethylase, KDM1, KDM1B, KDM2, KDM5, KDM5A, KDM5B, KDM5b/JARID1b, KDM5C, KDM5D, Lid, little imaginal discs, LSD1, lysine demethylase, lysine demethylase 5b, lysine demethylase 7, lysine-specific demethylase, lysine-specific demethylase 1, lysine-specific demethylase 5A, lysine-specific demethylase 5B, lysine-specific demethylase JMJ703, Lysine-specific demethylase SE14, More, Ndy1, Os03g0151300, PHD finger protein 8, PHF8, PKDM7B, PLU-1, PLU1, RB-binding protein 2, RBP2, RBR-2, retinoblastoma binding protein 2, SE14, SMCX, trimethylated lysine 4 of histone H3 demethylase
ECTree
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Benevolenskaya, E.V.
Histone H3K4 demethylases are essential in development and differentiation
Biochem. Cell Biol.
85
435-443
2007
Drosophila sp. (in: flies), Mus musculus (Q3UXZ9), Danio rerio (Q6IQX0)
Klose, R.J.; Yan, Q.; Tothova, Z.; Yamane, K.; Erdjument-Bromage, H.; Tempst, P.; Gilliland, D.G.; Zhang, Y.; Kaelin, W.G.
The retinoblastoma binding protein RBP2 is an H3K4 demethylase
Cell
128
889-900
2007
Mus musculus
Secombe, J.; Eisenman, R.N.
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection
Cell Cycle
6
1324-1328
2007
Drosophila sp. (in: flies)
Yamane, K.; Tateishi, K.; Klose, R.J.; Fang, J.; Fabrizio, L.A.; Erdjument-Bromage, H.; Taylor-Papadimitriou, J.; Tempst, P.; Zhang, Y.
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
Mol. Cell
25
801-812
2007
Homo sapiens
Eissenberg, J.C.; Lee, M.G.; Schneider, J.; Ilvarsonn, A.; Shiekhattar, R.; Shilatifard, A.
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase
Nat. Struct. Mol. Biol.
14
344-346
2007
Drosophila melanogaster (Q9VMJ7), Drosophila melanogaster
Tahiliani, M.; Mei, P.; Fang, R.; Leonor, T.; Rutenberg, M.; Shimizu, F.; Li, J.; Rao, A.; Shi, Y.
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Nature
447
601-605
2007
Homo sapiens (P41229)
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Characterization of Drosophila melanogaster JmjC+N histone demethylases
Nucleic Acids Res.
36
2852-2863
2008
Drosophila melanogaster, Drosophila melanogaster (Q9V333), Drosophila melanogaster (Q9V6L0)
Xiang, Y.; Zhu, Z.; Han, G.; Ye, X.; Xu, B.; Peng, Z.; Ma, Y.; Yu, Y.; Lin, H.; Chen, A.P.; Chen, C.D.
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
Proc. Natl. Acad. Sci. USA
104
19226-19231
2007
Homo sapiens
Seneda, M.M.; Godmann, M.; Murphy, B.D.; Kimmins, S.; Bordignon, V.
Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary
Reproduction
135
829-838
2008
Sus scrofa, Sus scrofa (A1YVX4)
Kavi, H.H.; Birchler, J.A.
Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization
BMC Res. Notes
2
217
2009
Drosophila melanogaster
Pasini, D.; Hansen, K.; Christensen, J.; Agger, K.; Cloos, P.; Helin, K.
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
Genes Dev.
22
1345-1355
2008
Mus musculus
Dey, B.; Stalker, L.; Schnerch, A.; Bhatia, M.; Taylor-Papidimitriou, J.; Wynder, C.
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation
Mol. Cell. Biol.
28
5312-5327
2008
Mus musculus
Lee, N.; Erdjument-Bromage, H.; Tempst, P.; Jones, R.S.; Zhang, Y.
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3
Mol. Cell. Biol.
29
1401-1410
2009
Drosophila melanogaster
Lopez-Bigas, N.; Kisiel, T.; DeWaal, D.; Holmes, K.; Volkert, T.; Gupta, S.; Love, J.; Murray, H.; Young, R.; Benevolenskaya, E.
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation
Mol. Cell
31
520-530
2008
Homo sapiens
Lee, J.; Thompson, J.; Botuyan, M.; Mer, G.
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor
Nat. Struct. Mol. Biol.
15
109-111
2008
Homo sapiens (O75164)
Zhou, W.; Chen, H.; Zhang, L.
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor
BMB Rep.
42
154-159
2009
Homo sapiens
Liefke, R.; Oswald, F.; Alvarado, C.; Ferres-Marco, D.; Mittler, G.; Rodriguez, P.; Dominguez, M.; Borggrefe, T.
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Genes Dev.
24
590-601
2010
Mus musculus
Zhang, Y.Z.; Zhang, Q.H.; Ye, H.; Zhang, Y.; Luo, Y.M.; Ji, X.M.; Su, Y.Y.
Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia
Neurosci. Res.
68
66-72
2010
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Grafodatskaya, D.; Chung, B.H.; Butcher, D.T.; Turinsky, A.L.; Goodman, S.J.; Choufani, S.; Chen, Y.A.; Lou, Y.; Zhao, C.; Rajendram, R.; Abidi, F.E.; Skinner, C.; Stavropoulos, J.; Bondy, C.A.; Hamilton, J.; Wodak, S.; Scherer, S.W.; Schwartz, C.E.; Weksberg, R.
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
BMC Med. Genomics
6
0000
2013
Homo sapiens
Janzer, A.; Stamm, K.; Becker, A.; Zimmer, A.; Buettner, R.; Kirfel, J.
The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts
J. Biol. Chem.
287
30984-30992
2012
Mus musculus
Chen, Q.; Chen, X.; Wang, Q.; Zhang, F.; Lou, Z.; Zhang, Q.; Zhou, D.X.
Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice
PLoS Genet.
9
e1003239
2013
Oryza sativa (Q53WJ1), Oryza sativa
El Mansouri, F.; Nebbaki, S.; Kapoor, M.; Afif, H.; Martel-Pelletier, J.; Pelletier, J.; Benderdour, M.; Fahmi, H.
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
Arthritis Res. Ther.
16
R113
2014
Homo sapiens (O60341), Homo sapiens
Maina, P.K.; Shao, P.; Jia, X.; Liu, Q.; Umesalma, S.; Marin, M.; Long, D.; Concepcion-Roman, S.; Qi, H.H.
Histone demethylase PHF8 regulates hypoxia signaling through HIF1alpha and H3K4me3
Biochim. Biophys. Acta
1860
1002-1012
2017
Homo sapiens
Ryu, H.; Ahn, S.
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
BMC Biol.
12
75
2014
Saccharomyces cerevisiae (P47156), Saccharomyces cerevisiae
Tumber, A.; Nuzzi, A.; Hookway, E.S.; Hatch, S.B.; Velupillai, S.; Johansson, C.; Kawamura, A.; Savitsky, P.; Yapp, C.; Szykowska, A.; Wu, N.; Bountra, C.; Strain-Damerell, C.; Burgess-Brown, N.A.; Ruda, G.F.; Fedorov, O.; Munro, S.; England, K.S.; Nowak, R.P.; Schofield, C.J.; La Thangue, N.B.; Pawlyn, C.
Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells
Cell Chem. Biol.
24
371-380
2017
Homo sapiens (P29375), Homo sapiens (P41229), Homo sapiens (Q9BY66), Homo sapiens (Q9UGL1)
Zhao, D.; Zhang, Q.; Liu, Y.; Li, X.; Zhao, K.; Ding, Y.; Li, Z.; Shen, Q.; Wang, C.; Li, N.; Cao, X.
H3K4me3 demethylase Kdm5a is required for NK cell activation by associating with p50 to suppress SOCS1
Cell Rep.
15
288-299
2016
Mus musculus (Q3UXZ9)
Klein, B.J.; Piao, L.; Xi, Y.; Rincon-Arano, H.; Rothbart, S.B.; Peng, D.; Wen, H.; Larson, C.; Zhang, X.; Zheng, X.; Cortazar, M.A.; Pena, P.V.; Mangan, A.; Bentley, D.L.; Strahl, B.D.; Groudine, M.; Li, W.; Shi, X.; Kutateladze, T.G.
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers
Cell Rep.
6
325-335
2014
Homo sapiens (Q9UGL1)
Mariani, L.; Lussi, Y.C.; Vandamme, J.; Riveiro, A.; Salcini, A.E.
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1
Development
143
851-863
2016
Caenorhabditis elegans (Q23541), Caenorhabditis elegans
Yu, X.; Chen, H.; Zuo, C.; Jin, X.; Yin, Y.; Wang, H.; Jin, M.; Ozato, K.; Xu, S.
Chromatin remodeling demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation
FASEB J.
32
552-567
2017
Mus musculus (Q3UXZ9), Mus musculus
Shen, Y.; Conde E Silva, N.; Audonnet, L.; Servet, C.; Wei, W.; Zhou, D.X.
Over-expression of histone H3K4 demethylase gene JMJ15 enhances salt tolerance in Arabidopsis
Front. Plant Sci.
5
290
2014
Arabidopsis thaliana (O64752), Arabidopsis thaliana Col-0 (O64752)
Nishibuchi, G.; Shibata, Y.; Hayakawa, T.; Hayakawa, N.; Ohtani, Y.; Sinmyozu, K.; Tagami, H.; Nakayama, J.
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex
J. Biol. Chem.
289
28956-28970
2014
Homo sapiens (P29375), Caenorhabditis elegans (Q23541), Caenorhabditis elegans
Horton, J.R.; Engstrom, A.; Zoeller, E.L.; Liu, X.; Shanks, J.R.; Zhang, X.; Johns, M.A.; Vertino, P.M.; Fu, H.; Cheng, X.
Characterization of a linked Jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases
J. Biol. Chem.
291
2631-2646
2016
Homo sapiens (P29375), Homo sapiens (P41229), Homo sapiens (Q9UGL1)
Bavetsias, V.; Lanigan, R.M.; Ruda, G.F.; Atrash, B.; McLaughlin, M.G.; Tumber, A.; Mok, N.Y.; Le Bihan, Y.V.; Dempster, S.; Boxall, K.J.; Jeganathan, F.; Hatch, S.B.; Savitsky, P.; Velupillai, S.; Krojer, T.; England, K.S.; Sejberg, J.; Thai, C.; Donovan, A.; Pal, A.; Scozzafava, G.; Bennett, J.M.; Kawamu, A.
8-Substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors
J. Med. Chem.
59
1388-1409
2016
Homo sapiens (P41229), Homo sapiens (Q9UGL1)
Yokoo, T.; Saito, H.; Yoshitake, Y.; Xu, Q.; Asami, T.; Tsukiyama, T.; Teraishi, M.; Okumoto, Y.; Tanisaka, T.
Se14, encoding a JmjC domain-containing protein, plays key roles in long-day suppression of rice flowering through the demethylation of H3K4me3 of RFT1
PLoS ONE
9
e96064
2014
Oryza sativa Japonica Group (Q10RP4)
Soloveychik, M.; Xu, M.; Zaslaver, O.; Lee, K.; Narula, A.; Jiang, R.; Rosebrock, A.P.; Caudy, A.A.; Meneghini, M.D.
Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation
Sci. Rep.
6
37942
2016
Saccharomyces cerevisiae (P47156), Saccharomyces cerevisiae
Xiao, C.; Liu, Y.; Xie, C.; Tu, W.; Xia, Y.; Costa, M.; Zhou, X.
Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity
Toxicol. Sci.
145
80-89
2015
Homo sapiens (P29375), Homo sapiens
Lan, F.; Nottke, A.C.; Shi, Y.
Mechanisms involved in the regulation of histone lysine demethylases
Curr. Opin. Cell Biol.
20
316-325
2008
Caenorhabditis elegans (Q23541), Drosophila melanogaster (Q9VMJ7)
Polytarchou, C.; Pfau, R.; Hatziapostolou, M.; Tsichlis, P.
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress
Mol. Cell. Biol.
28
7451-7464
2008
Mus musculus
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Characterization of Drosophila melanogaster JmjC+N histone demethylases
Nucleic Acids Res.
36
2852-2863
2008
Drosophila melanogaster (Q9VT00), Drosophila melanogaster
Cui, X.; Jin, P.; Cui, X.; Gu, L.; Lu, Z.; Xue, Y.; Wei, L.; Qi, J.; Song, X.; Luo, M.; An, G.; Cao, X.
Control of transposon activity by a histone H3K4 demethylase in rice
Proc. Natl. Acad. Sci. USA
110
1953-1958
2013
Oryza sativa Japonica Group (Q53WJ1)
Kim, J.; Shin, S.; Subramaniam, M.; Bruinsma, E.; Kim, T.D.; Hawse, J.R.; Spelsberg, T.C.; Janknecht, R.
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
Biochem. Biophys. Res. Commun.
401
412-416
2010
Homo sapiens
Spedaletti, V.; Polticelli, F.; Capodaglio, V.; Schinina, M.E.; Stano, P.; Federico, R.; Tavladoraki, P.
Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana
Biochemistry
47
4936-4947
2008
Arabidopsis thaliana
Iwase, S.; Lan, F.; Bayliss, P.; de la Torre-Ubieta, L.; Huarte, M.; Qi, H.H.; Whetstine, J.R.; Bonni, A.; Roberts, T.M.; Shi, Y.
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
Cell
128
1077-1088
2007
Homo sapiens
Enkhbaatar, Z.; Terashima, M.; Oktyabri, D.; Tange, S.; Ishimura, A.; Yano, S.; Suzuki, T.
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family
Cell Cycle
12
2100-2112
2013
Homo sapiens
Kurup, J.; Campeanu, I.; Kidder, B.
Contribution of H3K4 demethylase KDM5B to nucleosome organization in embryonic stem cells revealed by micrococcal nuclease sequencing
Epigenetics Chromatin
12
20
2019
Mus musculus
-
Nicolas, E.; Lee, M.G.; Hakimi, M.A.; Cam, H.P.; Grewal, S.I.; Shiekhattar, R.
Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions
J. Biol. Chem.
281
35983-35988
2006
no activity in Schizosaccharomyces pombe
Horton, J.R.; Woodcock, C.B.; Chen, Q.; Liu, X.; Zhang, X.; Shanks, J.; Rai, G.; Mott, B.T.; Jansen, D.J.; Kales, S.C.; Henderson, M.J.; Cyr, M.; Pohida, K.; Hu, X.; Shah, P.; Xu, X.; Jadhav, A.; Maloney, D.J.; Hall, M.D.; Simeonov, A.; Fu, H.; Vertino, P.M.; Cheng, X.
Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A
J. Med. Chem.
61
10588-10601
2018
Homo sapiens
Wong, P.P.; Miranda, F.; Chan, K.V.; Berlato, C.; Hurst, H.C.; Scibetta, A.G.
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21cip (CDKN1A)
Mol. Cell. Biol.
32
1633-1644
2012
Homo sapiens
Longbotham, J.; Chio, C.; Dharmarajan, V.; Trnka, M.; Torres, I.; Goswami, D.; Ruiz, K.; Burlingame, A.; Griffin, P.; Fujimori, D.
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
Nat. Commun.
10
94
2019
Homo sapiens
Ciccone, D.N.; Su, H.; Hevi, S.; Gay, F.; Lei, H.; Bajko, J.; Xu, G.; Li, E.; Chen, T.
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
Nature
461
415-418
2009
Mus musculus
Yang, H.; Mo, H.; Fan, D.; Cao, Y.; Cui, S.; Ma, L.
Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis
Plant Cell Rep.
31
1297-1308
2012
Arabidopsis thaliana (O64752)
Yang, W.; Jiang, D.; Jiang, J.; He, Y.
A plant-specific histone H3 lysine 4 demethylase represses the floral transition in Arabidopsis
Plant J.
62
663-673
2010
Arabidopsis thaliana
Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
Proc. Natl. Acad. Sci. USA
108
7541-7546
2011
Homo sapiens
Longbotham, J.E.; Kelly, M.J.S.; Fujimori, D.G.
Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A
ACS Chem. Biol.
FEHLT
0000
2021
Homo sapiens (P29375)
Xu, L.; Wu, H.; Hu, X.
Histone demethylase KDM5A enhances cell proliferation, induces EMT in lung adenocarcinoma cells, and have a strong causal association with paclitaxel resistance
Acta Biochim. Pol.
68
593-602
2021
Homo sapiens (P29375), Homo sapiens
Vasconez, A.E.; Janetzko, P.; Oo, J.A.; Pflueger-Mueller, B.; Ratiu, C.; Gu, L.; Helin, K.; Geisslinger, G.; Fleming, I.; Schroeder, K.; Fork, C.; Brandes, R.P.; Leisegang, M.S.
The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3UTR of soluble epoxide hydrolase
Acta Physiol. (Oxf.)
225
e13168
2019
Mus musculus (Q80Y84)
Petronikolou, N.; Longbotham, J.E.; Fujimori, D.G.
Extended recognition of the histone H3 tail by histone demethylase KDM5A
Biochemistry
59
647-651
2020
Homo sapiens (P29375), Homo sapiens
Li, Q.M.; Li, J.L.; Feng, Z.H.; Lin, H.C.; Xu, Q.
Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells
Bioengineered
11
449-462
2020
Homo sapiens (P29375), Homo sapiens
Romani, M.; Daga, A.; Forlani, A.; Pistillo, M.P.; Banelli, B.
Targeting of histone demethylases KDM5A and KDM6B inhibits the proliferation of temozolomide-resistant glioblastoma cells
Cancers (Basel)
11
878
2019
Homo sapiens (P29375)
Zhao, B.; Liang, Q.; Ren, H.; Zhang, X.; Wu, Y.; Zhang, K.; Ma, L.; Zheng, Y.; Liu, H.
Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)
Eur. J. Med. Chem.
192
112161
2020
Homo sapiens (Q9UGL1)
Glanzner, W.G.; Gutierrez, K.; Rissi, V.B.; de Macedo, M.P.; Lopez, R.; Currin, L.; Dicks, N.; Baldassarre, H.; Agellon, L.B.; Bordignon, V.
Histone lysine demethylases KDM5B and KDM5C modulate genome activation and stability in porcine embryos
Front. Cell Dev. Biol.
8
151
2020
Sus scrofa, Sus scrofa (A1YVX4)
Guo, L.; Guo, Y.Y.; Li, B.Y.; Peng, W.Q.; Tang, Q.Q.
Histone demethylase KDM5A is transactivated by the transcription factor C/EBPbeta and promotes preadipocyte differentiation by inhibiting Wnt/beta-catenin signaling
J. Biol. Chem.
294
9642-9654
2019
Mus musculus (Q3UXZ9), Mus musculus
Pippa, S.; Mannironi, C.; Licursi, V.; Bombardi, L.; Colotti, G.; Cundari, E.; Mollica, A.; Coluccia, A.; Naccarato, V.; La Regina, G.; Silvestri, R.; Negri, R.
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
Molecules
24
1739
2019
Homo sapiens (Q9UGL1)
Wu, L.; Cao, J.; Cai, W.; Lang, S.; Horton, J.; Jansen, D.; Liu, Z.; Chen, J.; Zhang, M.; Mott, B.; Pohida, K.; Rai, G.; Kales, S.; Henderson, M.; Hu, X.; Jadhav, A.; Maloney, D.; Simeonov, A.; Zhu, S.; Iwasaki, A.; Hall, M.; Cheng, X.; Shadel, G.; Yan, Q
KDM5 histone demethylases repress immune response via suppression of STING
PLoS Biol.
16
e2006134
2018
Homo sapiens (P41229), Homo sapiens (Q9UGL1), Homo sapiens
Karia, D.; Gilbert, R.C.G.; Biasutto, A.J.; Porcher, C.; Mancini, E.J.
The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain
R. Soc. Open Sci.
7
191048
2020
Mus musculus (Q3UXZ9)
Dorosz, J.; Kristensen, L.H.; Aduri, N.G.; Mirza, O.; Lousen, R.; Bucciarelli, S.; Mehta, V.; Selles-Baiget, S.; Solbak, S.M.O.; Bach, A.; Mesa, P.; Hernandez, P.A.; Montoya, G.; Nguyen, T.T.T.N.; Rand, K.D.; Boesen, T.; Gajhede, M.
Molecular architecture of the Jumonji C family histone demethylase KDM5B
Sci. Rep.
9
4019
2019
Homo sapiens (Q9UGL1), Homo sapiens
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