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1.14.11.65: [histone H3]-dimethyl-L-lysine9 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-dimethyl-L-lysine9 demethylase, go to the full flat file.

Word Map on EC 1.14.11.65

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine9
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-L-lysine9
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AOF2, AtJMJ17, BHC110, G9A/KMT1C, GLP/KMT1D, H3K4me2 demethylase, H3K9 demethylase, H3K9 histone demethylase, H3K9 Jumonji demethylase, H3K9 mono- and di-demethylase, H3K9Me2 demethylase, H3K9me2 methylase, H3K9me3 methylase, hairless, hairless protein, HDM, histone demethylase, histone demethylase JMJD1C, histone H3 Lys 9 demethylase, histone H3 lysine 9 demethylase, histone H3 lysine 9 Jumonji demethylase, histone H3 lysine 9 mono- and di-demethylase, histone H3K9 demethylase, histone lysine demethylase, IBM1, JHDM2A, JMJ25, JMJ27, JmjC domain-containing protein 27, jmjC histone demethylase, JmjC-domain-containing histone demethylase 2A, JMJD1A, JMJD1B, JMJD2A, Jmjd2c histone demethylase, KDM1, KDM1A, Kdm3a, Kdm3b, KDM4A, KDM7A, KIAA0601, KIAA1718, LSD1, LSD1 demethylase, LSD1/KDM1, LSD2, lysine specific demethylase 1, lysine-specific demethylase 1, lysine-specific demethylase 1A, lysine-specific demethylase 3A, lysine-specific demethylase-1, lysine-specific histone demethylase 1, lysine-specific histone demethylase 2, More, NPAO, p110b, PHF8, PHF8/KIAA1718 histone demethylase, plant homeodomain finger protein 8, SPAC23E2.02, SPBC146.09c, Suv(Var)3-9/KMT1, SWIRM1, SWIRM2, Swm1, Swm1/2 complex, Swm2, [histone-H3]-lysine-4-demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.65 [histone H3]-dimethyl-L-lysine9 demethylase

Source Tissue

Source Tissue on EC 1.14.11.65 - [histone H3]-dimethyl-L-lysine9 demethylase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
osteoarthritic chondrocytes
Manually annotated by BRENDA team
enzyme JMJD1C is upregulated in patient esophageal cancer tissues and different esophageal cancer cell lines
Manually annotated by BRENDA team
3.3fold increase in mRNA after 6 h of hypoxia
Manually annotated by BRENDA team
during the differentiation of leukemic HL60 cells, the decreased hTERT expression is accompanied by the LSD1 recruitment to the hTERT promoter
Manually annotated by BRENDA team
1.8fold increase in mRNA after 6 h of hypoxia
Manually annotated by BRENDA team
the enzyme is mainly distributed in luminal epithelial cells of wild-type mammary glands
Manually annotated by BRENDA team
olfactory-placode-derived cell line, OP-6
Manually annotated by BRENDA team
-
lysine-specific demethylase 1 colocalizes with androgen receptor
Manually annotated by BRENDA team
protein level is the highest in round spermatids, compared with spermatocyte and elogating spermatids
Manually annotated by BRENDA team
high expression at both mRNA and protein level, significant increase during spermatogenesis. Expression during and after meiosis, preceding the expression of transition proteins and protamines
Manually annotated by BRENDA team
additional information