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1.14.11.65: [histone H3]-dimethyl-L-lysine9 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-dimethyl-L-lysine9 demethylase, go to the full flat file.

Word Map on EC 1.14.11.65

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine9
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-L-lysine9
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AOF2, AtJMJ17, BHC110, G9A/KMT1C, GLP/KMT1D, H3K4me2 demethylase, H3K9 demethylase, H3K9 histone demethylase, H3K9 Jumonji demethylase, H3K9 mono- and di-demethylase, H3K9Me2 demethylase, H3K9me2 methylase, H3K9me3 methylase, hairless, hairless protein, HDM, histone demethylase, histone demethylase JMJD1C, histone H3 Lys 9 demethylase, histone H3 lysine 9 demethylase, histone H3 lysine 9 Jumonji demethylase, histone H3 lysine 9 mono- and di-demethylase, histone H3K9 demethylase, histone lysine demethylase, IBM1, JHDM2A, JMJ25, JMJ27, JmjC domain-containing protein 27, jmjC histone demethylase, JmjC-domain-containing histone demethylase 2A, JMJD1A, JMJD1B, JMJD2A, Jmjd2c histone demethylase, KDM1, KDM1A, Kdm3a, Kdm3b, KDM4A, KDM7A, KIAA0601, KIAA1718, LSD1, LSD1 demethylase, LSD1/KDM1, LSD2, lysine specific demethylase 1, lysine-specific demethylase 1, lysine-specific demethylase 1A, lysine-specific demethylase 3A, lysine-specific demethylase-1, lysine-specific histone demethylase 1, lysine-specific histone demethylase 2, More, NPAO, p110b, PHF8, PHF8/KIAA1718 histone demethylase, plant homeodomain finger protein 8, SPAC23E2.02, SPBC146.09c, Suv(Var)3-9/KMT1, SWIRM1, SWIRM2, Swm1, Swm1/2 complex, Swm2, [histone-H3]-lysine-4-demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.65 [histone H3]-dimethyl-L-lysine9 demethylase

IC50 Value

IC50 Value on EC 1.14.11.65 - [histone H3]-dimethyl-L-lysine9 demethylase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.019
7-[(5-aminopentyl)oxy]-6-methoxy-N2,N2,N4,N4-tetramethylquinazoline-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.0034
7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.0037
7-[(5-aminopentyl)oxy]-N4-(1-benzylpiperidin-4-yl)-N2-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00484
H3 1-21 peptide
Homo sapiens
pH 7.5, 25°C, recombinant enzyme
-
0.000153
histone H3
Homo sapiens
pH 7.5, 25°C, recombinant enzyme
-
0.0165
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.067
N-oxalylglycine
Homo sapiens
pH and temperature not specified in the publication
0.00484
peptide H31-21
Homo sapiens
pH 7.5, 25°C
-