1.14.11.64: glutarate dioxygenase

This is an abbreviated version!
For detailed information about glutarate dioxygenase, go to the full flat file.

Reaction

Synonyms

csiD, GlaH, glutarate 2-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.64 glutarate dioxygenase

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Results	in table
1186	AA Sequence
1	Crystallization (Commentary)
2	General Information
2	Inhibitors
2	KM Value [mM]
2	Organism
4	Pathway
1	Reaction
2	Reference
1	Specific Activity [micromol/min/mg]
3	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

General Information

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General Information on EC 1.14.11.64 - glutarate dioxygenase

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metabolism

Pseudomonas putida

Q88IU0

GntR family protein, CsiR, and LysR family protein, GcdR, regulate the catabolism of glutarate by repressing the transcription of csiD and lhgO, two key genes in the glutarate hydroxylation pathway, and by activating the transcription of gcdH and gcoT, two key genes in the glutaryl-CoA dehydrogenation pathway, respectively

754595

physiological function

Escherichia coli

P76621

during catabolism of lysine to succinate, CsiD acts as an 2-oxoglutarate-dependent dioxygenase catalysing hydroxylation of glutarate to L-2-hydroxyglutarate. Repression of the pathway by CsiR is relieved upon glutarate binding. In a knockout strain, with carbon starvation and entry into the stationary phase, the intracellular concentration of glutarate accumulates to much higher levels than compared to the wild-type

754854