1.14.11.63: peptidyl-lysine (3S)-dioxygenase

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For detailed information about peptidyl-lysine (3S)-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.63

1.14.11.63

histone

demethylases

trafac

jumonji-c

jarid2

prdm10

hif1an

clipping

gametogenesis

Reaction

Synonyms

JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.63 peptidyl-lysine (3S)-dioxygenase

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Results	in table
4	AA Sequence
1	Application
1	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
7	IC50 Value
7	Inhibitors
2	Localization
2	Natural Substrates/ Products (Substrates)
6	Organism
1	Protein Variants
1	Reaction
6	Reference
1	Source Tissue
6	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name

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Reference on EC 1.14.11.63 - peptidyl-lysine (3S)-dioxygenase

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751645

Markolovic, S.; Zhuang, Q.; Wilkins, S.E.; Eaton, C.D.; Abboud, M.I.; Katz, M.J.; McNeil, H.E.; Lesniak, R.K.; Hall, C.; Struwe, W.B.; Konietzny, R.; Davis, S.; Yang, M.; Ge, W.; Benesch, J.L.P.; Kessler, B.M.; Ratcliffe, P.J.; Cockman, M.E.; Fischer, R.; Wappner, P.; Chowdhury, R.; Coleman, M.L.; Schofield, C.J.

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Nat. Chem. Biol.

688-695

2018

Drosophila melanogaster (Q9VU77), Homo sapiens (P0C870)

29915238

752053

Liu, H.; Wang, C.; Lee, S.; Deng, Y.; Wither, M.; Oh, S.; Ning, F.; Dege, C.; Zhang, Q.; Liu, X.; Johnson, A.M.; Zang, J.; Chen, Z.; Janknecht, R.; Hansen, K.; Marrack, P.; Li, C.Y.; Kappler, J.W.; Hagman, J.; Zhang, G.

Clipping of arginine-methylated histone tails by JMJD5 and JMJD7

Proc. Natl. Acad. Sci. USA

114

E7717-E7726

2017

Mus musculus (P0C872)

28847961

764299

Zhang, W.; Li, K.; Wang, T.; Wu, M.; Li, L.

Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation

Bioorg. Med. Chem. Lett.

128139

2021

Homo sapiens (P0C872)

34048880

765489

Cheng, Y.; Wang, Y.; Li, J.; Chang, I.; Wang, C.Y.

A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival

Oncotarget

1972-1982

2017

Homo sapiens (P0C870)

28030848

765815

Liu, H.; Wang, C.; Lee, S.; Ning, F.; Wang, Y.; Zhang, Q.; Chen, Z.; Zang, J.; Nix, J.; Dai, S.; Marrack, P.; Hagman, J.; Kappler, J.; Zhang, G.

Specific recognition of arginine methylated histone tails by JMJD5 and JMJD7

Sci. Rep.

3275

2018

Mus musculus (P0C872)

29459673