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1.14.11.63: peptidyl-lysine (3S)-dioxygenase

This is an abbreviated version!
For detailed information about peptidyl-lysine (3S)-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.63

Reaction

a [protein]-L-lysine
+
2-oxoglutarate
 +
O2
=
a [protein]-(3S)-3-hydroxy-L-lysine
 +
succinate
 +
CO2

Synonyms

JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.63 peptidyl-lysine (3S)-dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.63 - peptidyl-lysine (3S)-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid
-
-
2-[3-(3,4-dimethoxyphenyl)propanamido]benzoic acid
-
-
3-amino-N-[3-(4-amino-4-methylcyclohexyl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]-2,3-dihydropyrazine-2-carboxamide
-
-
5-(1,3-benzothiazol-2-yl)-N-propylthiophene-2-carboxamide
-
-
7-[phenyl[(pyridin-2-yl)amino]methyl]quinolin-8-ol
-
ethyl 2-[[(4-nitrophenyl)methanesulfonyl]carbamoyl]pyridine-4-carboxylate
-
-
[8-[(2,4-dichlorobenzoyl)oxy]quinolin-5-yl]azinic acid
compound efficiently binds to JMJD7 in vitro. In a cellular assay, the compound displays good inhibitory activity against cancer cell lines expressing a high level of JMJD7
-