1.14.11.61: feruloyl-CoA 6-hydroxylase

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For detailed information about feruloyl-CoA 6-hydroxylase, go to the full flat file.

Word Map on EC 1.14.11.61

1.14.11.61

coumarins

dioxygenase

rhizosphere

exudate

scopolin

nicotiana

microbiome

phenylpropanoids

2-oxoglutarate-dependent

phytoalexins

attenuata

iron-mobilizing

alternata

simiae

benthamiana

ja-deficient

deficiency-induced

Reaction

Synonyms

CYP98A22, F6'H1, F6'H2, F6'H2_3, F6'H3, F6H1-2, F6H1-3, feruloyl CoA ortho-hydroxylase 1, feruloyl-CoA 6'-hydroxylase 1

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.61 feruloyl-CoA 6-hydroxylase

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Results	in table
220	AA Sequence
1	Application
2	Cloned(Commentary)
1	Crystallization (Commentary)
4	Expression
5	General Information
1	Inhibitors
1	kcat/KM [mM/s]
1	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
11	Organism
4	Pathway
1	pH Optimum
1	Reaction
11	Reference
9	Source Tissue
8	Substrates and Products (Substrate)
1	Subunits
12	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.11.61 - feruloyl-CoA 6-hydroxylase

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feruloyl-CoA,2-oxoglutarate:oxygen oxidoreductase (6-hydroxylating)

Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. cf. EC 1.14.11.62, trans-4-coumaroyl-CoA 2-hydroxylase.