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1.14.11.51: DNA N6-methyladenine demethylase

This is an abbreviated version!
For detailed information about DNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.51

Reaction

N6-methyladenine in DNA
+
2-oxoglutarate
 +
O2
=
adenine in DNA
 +
formaldehyde
 +
succinate
 +
CO2

Synonyms

6mA DNA demethylase, ALKBH1, DMAD, DNA 6mA demethylase, NMAD, NMAD-1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.51 DNA N6-methyladenine demethylase

Crystallization

Crystallization on EC 1.14.11.51 - DNA N6-methyladenine demethylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme shows a stretch-out conformation of its Flip1 motif, explaining the observed preference of ALKBH1 for unpairing substrates, in which the flipped N6-mA is primed for catalysis. Structures of ALKBH1 bound to a 21-mer bulged DNA show the need of both flanking duplexes and a flipped base for recognition and catalysis
structure to 3.1 A resolution. The N-terminal domain of the protein forms close contacts with the core catalytic domain and might be responsible for the recognition of nucleic acid substrates. H231, D233 and H287 are ligands of the catalytic iron metal